Friday, October 21, 2016

President Obama’s Legacy Gets A Moonshot Lift With A Song — "Time Is Luck Love With A O"


Austin ( BMJSports) — Sports Medicine Journal Barron’s Medical Journal And Its Sports Department BMJSports is giving A Concert/FundRaiser At BeyoncĂ© Noel’s Dad, Mathew Knowles House Of Dereon on the same week Vice President Biden is giving the Obama Administration its Final Cancer Moonshot Report. This week is special for two reasons , The House Of Dereon is sold and will be destroyed and the single best collaborative effort between The President And Vice President, Cancer Moonshot has all the promise of ending cancer as we know it, has taken wings. The best example of the promise to end cancer is Today in the Oval Office, Vice President Joe Biden delivered the Cancer Moonshot report to the President and the American public. The report summarizes the work of the Cancer Moonshot Task Force since its creation in January, and lays out the Vice President’s strategic plan for transforming cancer research and care. The report also includes the Cancer Moonshot Blue Ribbon Panel’s identified areas of scientific opportunity. live Video Accompanying these findings and recommendations, today’s report includes the announcement of new commitments toward the goals of the Cancer Moonshot from both the public and private sectors. For example, today the National Cancer Institute, Amazon Web Services, and Microsoft are announcing a collaboration to build a sustainable model for maintaining cancer genomic data in the cloud. The information stored there will be available to cancer researchers through the NCI’s Genomic Data Commons and Cancer Genomics Cloud programs. The Department of Defense (DoD) is establishing a groundbreaking new study to transform our understanding of the biological basis of cancer. Using the vast amount of data housed within DoD’s cancer registry database and biological sample collection, researchers will have at their fingertips potentially 250,000 samples to uncover new connections between the earliest signs of cancer. Findings can then be linked to information housed within the Environmental Protection Agency’s databases to further accelerate our understanding of the environmental factors contributing to disease progression. And today Lyft and Uber expand their support of affordable, reliable transportation for cancer patients because currently one fourth of patients miss or reschedule their treatments and appointments because of transportation issues. For example, Lyft commits to expand its Boston-based “Treatment Transport” partnership to all 200+ cities Lyft currently serves by 2020, to provide patients, particularly those from low income communities, with credits to receive free transportation to and from treatments. And Uber sets a goal to connect millions of patients with rides annually, in over 500 cities by 2018. Moonshot End Cancer Tour by BMJSports & American Cancer Society — Presents President Obama Vision Moonshot — Joe Biden Legacy — Michelle Obama Passion For Helping Women – & Khiara Singer & SongWriter New Single OverCome To Benefit American Cancer Society https://www.eventbrite.com/e/breast-cancer-awareness-month-benefit-concert-bmjsports-presents-an-evening-of-music-with-miss-tickets-27648209539?aff=efbneb Ms Universe Are Wonderful Women That Give Back To Their Communities: Ms Universe Bahamas 2009 Khiara Is Recording A Cancer Cure Song To Benefit American Cancer Society In Houston Texas Khiara Says “Happiness Happens When You Love Your Career — Joined On A Special Day With Your Love One — & Be Part Of The Making Of A Video & Premier Concert : ” https://www.eventbrite.com/e/time-is-luck-love-with-an-o-2016-to-be-recorded-live-tickets-27648209539 —–Cure For Cancer Hit Song Live Recording & Video — —– Khiara Sherman In Houston Texas October 22, 2016 —– The House Of Dereon — “Black – White or Pink” — American Cancer Society — “Cancer Month Awareness Benefit BMJSports American Cancer Society SWAC Moonshot EndCancer Concert Tour : Our Goal Is To Ensure That Young Historically Black Universities Produce Scientists, Engineers & Biologists To Be A Part Of Vice President Joe Biden’s #Moonshot Khiara Sherman — “Happiest Happens When You Love Your Career — Join On A Special Day With Your Love One — & Be Part Of The Making Of A Video & Live Record Recording Concert : ” Jacob Marsh Ex Chapter President of Sam Houston The Theta Mu Chapter of Alpha Phi Alpha Fraternity Inc. is hosting the Pink, White, and Black —–Cure For Cancer Hit Song Live Recording & Video — —– In Houston Texas October 22, 2016 —– — Featuring Khiara Sherman & The Real BeerFest —- – One Of The Most Beautiful #Women In The World – Courageous Brave & Fearless Musical Sound – Musical Discipline From Years Of International Performances – Musical Sound With Volume, Capacity Only Measured By Genius The reason Why cancer is on its way out is because of the efforts of women like Sharon Dewitt and Patrica Kanuha dedication to the excellence to the BMJSports Moonshot Endcancer Concert and Tour

Wednesday, September 7, 2016

President Obama — Legacy Contribution Is Clearly BlackShear Field


President Obama — Legacy Contribution Is Clearly BlackShear Field

Austin ( BMJSports ) — If You Ever Lived In Prairie View Texas As A Young Man — Where Ever You Go — PV Stays With You : For PVAMU Is A Moveable Feast — Progress In Our Life Time.

President Obama — Legacy Contribution is Clearly BlackShear Field Opening on September 4, 2016 — As The Social Event Of The Year — As Far as you can see smiles of joy and A “Since of Pride ” — You only Witness when there is A Amazing Event — Like The United States Of America Nominates The First African American President. Both Prairie View & Texas Southern Universities Presidents George C. Wright And Dr. Austin A. Lane glowing with “Pride” — BMJSports Caught up with Wright and His Wife walking the Grounds With A Amazement — Much like Denzel Washington winning A Oscar . Had Gumbo in The Press Box Area with Lane and his lovely wife again all this made possible with the leadership from President Obama and His Wife . With His daughter walking on campus Kenny Houston — The Hall Of Fame Football Player From The Washington Redskins. We discussed the shoulders we all where walking on. Prairie Vew’s head coach — Simmons said the “Panthers, who averaged nearly 45 points a game last year, again will play an up-tempo offense and try to snap the ball before the play clock hits 18 seconds.” “We’re going to have to weather the storm early because they are going to be extremely excited, flying around making plays and we’re going to have to play at the same speed,” Haywood said. TSU athletic director Dr. Charles McClelland is banking that Haywood, who has coached under Nick Saban, Mack Brown and Charlie Weis, can match the success of what men’s basketball coach Mike Davis has accomplished for the Tigers. In The Very near future. One thing is for sure The LaborDay Classic Is In Great Hands B Bobby Graham -B .G










`



Wednesday, July 6, 2016

The Legacy Of President Obama : A Cancer Cure


The Legacy Of President Obama : A Cancer Cure BMJSports ( Austin, TX USA ) --- President Obama's Legacy And Vice President Biden passion is to ensure as many American as possible have Health Care with now a focus on a Cure For Cancer. Vice President Biden Announces New Actions to Accelerate Progress Toward Ending Cancer As We Know It Barron's Medical Sports Division BMJSport was wondering if there is a College Football -- Athlete who will team up with The VP to come with a cancer cure. We decided to produce a , BMJSports American Cancer Society ‪#‎SWAC‬ ‪#‎Moonshot‬ ‪#‎EndCancer‬ Concert Tour to find out. Our Goal Is To Ensure That Young Historically Black Universities Produce Scientists, Engineers & Biologists To Be A Part Of Vice President Joe Biden's #Moonshot Initiative to Cure Cancer. First Stop Of Our Tour:... Prairie View A&M University vs Texas Southern University Bayou City Classic September 3, 2016 Brought To You Buy: Performing: International Singing Star and Former Miss Universe The Bahamas 2009, Khiara , joined by the fabulous Greeters of Honolulu Houston of Honolulu Hula – Houston led by Rick Man talented singer/songwriter Lilly Aviana and North America’s latest superstar rap group from Houston, Trillgang worldwide featuring Jorge Rosario aka Beerfest and lead by Makana Kanuha aka ‪#‎Johniixo‬, all brought together by Producer, Patricia Kanuha from the island of Oahu in beautiful ‪#‎Hawaii‬. Patricia Kanuha has put together a unique show/sound that ranges from the Bahamas all the way through to Hawaii mixed in with the H-Town rap scene. 2nd Stop Southern Heritage Classic on Sept. 10. Jackson State University Tigers football Vs Tennessee State University Tigers in Memphis, ‪#‎Tennessee‬ ---- Sports Caster ‪#‎ButchAlsandor‬ --- (Will Tell You This Is A Big Game ) ‪#‎AmericanCancerSociety‬ #SWAC #Moonshot ‪#‎Cancer‬ Concert Tour Sample video from Khiara Sherman ---http://youtu.be/j36HcUOTlOQ ( We have Extended An Invitation To Dr.Thomas Freeman Of Texas Southern University (‪#‎TSU‬ ) - To Be The Honorary Chair -- Dr. Thomas Freeman taught Dr. Martin Luther King Jr and Barbara Jordan, how to debate who honed her oratory skills as a debater ) #AmericanCancerSociety event --- Tune in to the live Global Celebration telecast on August 19 , 2016 at 8 p.m. EST, when we will all join together to kick off to the 2017 Relay For Life event season! Check back closer to the event for live viewing links and instructions! https://www.eventbrite.com/e/bmjsports-2016-140th-year-pvu-… Darian Ward Amanda K. Edwards Patricia Kanuha Professor Carliss Chatman Vicky Heileman Pink Argo Reinhard Khiara Sherman Lilly Aviana Sonya Portales Miller Makana Kanuha Rick Man Details on the MoonShoot Program: In conjunction with the Summit, the Vice President is announcing a set of new public and private sector actions to drive progress toward ending cancer as we know it. Federal agencies have come together as part of the Cancer Moonshot Task Force and are announcing today additional investments, improved policies, and new private sector partnerships focused on catalyzing new scientific breakthroughs, unleashing the power of data, accelerating bringing new therapies to patients, strengthening prevention and diagnosis, and improving patient access and care. Additionally, in response to the Vice President’s call to action, the private, philanthropic, and academic sectors, along with the patient advocacy community, have stepped up with new collaborations and actions aligned with the goals of the Cancer Moonshot. More details on all of these announcements can be found below. Background In his final State of the Union address, President Obama put Vice President Biden in charge of a new national effort to end cancer as we know it. The goal of this Cancer Moonshot is to double the rate of progress toward a cure – to make a decade of advances in cancer prevention, diagnosis, treatment, and care in five years. Since that announcement, the President has issued a Presidential Memorandum establishing a first-of-its-kind Cancer Moonshot Task Force, bringing together every federal agency that has a part to play in the fight against cancer. Agencies are convening under the leadership of the Vice President to ensure that we make the most of our federal investments, research and data, computing capabilities, targeted incentives, private-sector efforts, and patient-engagement initiatives. In February, the White House announced a $195 million investment at the National Institutes of Health (NIH) in Fiscal Year 2016 as part of a proposed nearly $1 billion budget initiative for the Cancer Moonshot. Vice President Biden has travelled to a number of leading cancer centers in the United States and to venues around the world to engage experts throughout the community – researchers, oncologists, patients and patient advocates, industry leadership, and data and technology experts, among others. Through these conversations, the Vice President identified the barriers and opportunities that he could most usefully take on as part of the Cancer Moonshot and he issued a call to action for individuals and organizations to join the effort by launching new collaborations to address those challenges. Cancer Moonshot Task Force Announcements To make the most of these opportunities, the Cancer Moonshot Task Force and individual Federal agencies are announcing the following set of activities to support the goals of the Cancer Moonshot: Expediting Researchers’ Access to Cancer Compounds for Research– National Cancer Institute Drug Formulary: Leveraging lessons learned through the National Cancer Institute (NCI)-MATCH clinical trial in which agents from different companies are tested alone or in combination under a single study, NCI is forging a public-private partnership with 20-30 pharmaceutical and biotechnology companies to expedite cancer researchers’ access to investigational agents and approved drugs. Researchers will be able to obtain compounds through one pre-approved “formulary” list and test them for new purposes or in new combinations, thereby alleviating the need to negotiate with each company independently for individual research projects, which can take as long as 18 months. Ultimately this approach will expedite the start of clinical trials and will bring new options to cancer patients faster. The first agents are expected to be available to the research community by the end of the year. Making Clinical Research Trials More Accessible to Cancer Patients: Today, the National Cancer Institute (NCI), in partnership with the White House Presidential Innovation Fellows, is announcing its plan for re-designing how patients and oncologists learn about and find information about cancer clinical trials. The goal is to ensure that patients and their care teams have access to the information they need at the right time, as well as strengthen participation in cancer research studies to help accelerate medical discoveries and treatments for cancer. The first phase will make cancer clinical data hosted on cancer.gov available through an application programming interface (API) for advocacy groups, academia, and others in the cancer ecosystem to access directly. The API will enable third-party innovators, including Smart Patients, Syapse, Cure Forward, and Trial Reach, to use the new cancer clinical trial API to build applications, integrations, search tools, and digital platforms tailored to individual communities that bring clinical trial information to more providers, patients, and their family members. Strategic Computing Partnership between the Department of Energy and the National Cancer Institute to Accelerate Precision Oncology: The Department of Energy (DOE), in partnership with the National Cancer Institute (NCI), is today announcing the launch of three new pilot projects focused on bringing together nearly one hundred cancer researchers, care providers, computer scientists, and engineers to apply the nation's most advanced supercomputing capabilities to analyze data from preclinical models in cancer, molecular interaction data for RAS, and cancer surveillance data across four DOE National Laboratories: Argonne, Los Alamos, Lawrence Livermore, and Oak Ridge, in conjunction with the NCI Frederick National Laboratory for Cancer Research. By joining these forces under a coordinated effort, these new projects will refine our understanding of the mechanisms leading to cancer development and thereby accelerate the development of promising therapies that are more effective and less toxic. Creation of an Open Access Resource for Sharing Cancer Data via the Genomic Data Commons: As part of the Cancer Moonshot and the President’s Precision Medicine Initiative, Foundation Medicine is more than doubling the total number of patients represented within the NCI's Genomic Data Commons (GDC), bringing its total to over 32,000 patients accumulated in just over a month. At its launch in early June, the GDC already shared more than five petabytes of raw unprocessed genomic data from large research projects on nearly thirty tumor types from more than 14,000 patients, along with associated clinical data (e.g. clinical diagnosis, treatment history, survival data), creating a foundational system for broad sharing and analysis of cancer genomic data, which is critical for advancing the field of precision medicine and improving the care of cancer patients. Harnessing Big Data to Transform Veteran Health through Precision Medicine: Today the Department of Veterans Affairs (VA) and the Department of Energy (DOE) are announcing a new collaboration to apply the most powerful computational assets at the DOE’s National Labs to nearly half a million veterans' records from one of the world's largest research cohorts -- the Million Veteran Program, a cornerstone of the President’s Precision Medicine Initiative. This is a 5-year, renewable commitment with $3.5 million allocated in Fiscal Year 2016. The first phase of this partnership will focus on cancer, cardiovascular disease, and mental health issues, and the resulting platform will accelerate our understanding of disease detection, progression, prevention, and treatment by combining the rich clinical, environmental, and genomic data – all while enabling top researchers in the world to perform the most cutting-edge science. Creation of a New Program to Accelerate Cancer Product Regulatory Review: The Food and Drug Administration (FDA) is excited to announce the hiring of Dr. Richard Pazdur as Acting Director of its new Oncology Center of Excellence (OCE). The OCE will unite cancer product regulatory review to enhance coordination and leverage the combined skills and clinical expertise across FDA centers. Under the Cancer Moonshot, the Acting Director is charged with accelerating the establishment of a program that brings together oncologists across the FDA in an effort to expedite the development of novel cancer-related drugs, biologics, and devices and support an integrated approach to tackling this devastating disease. Patents 4 Patients: Establishment of Fast-Track Review for Cancer Treatment-Related Patents: The U.S. Patent and Trademark Office (USPTO) is launching this month a free and accelerated pilot program that aims to cut in half the time it takes to review patent applications in select fields of cancer therapy (in less than 12 months). This “fast track” will be open to any applicant, including early stage biotechnology companies, universities, and large pharmaceutical firms alike, and entities who have products already in FDA approved clinical trials will be able to opt into the acceleration program. With approximately 900 applications received annually from around the world in the cancer immunotherapy space alone, this pilot program aims to catalyze innovative new treatments from conception through regulatory approval in order to reach the patient's bedside faster. National Institute of Health (NIH) Public-Private Partnership for Accelerating Cancer Therapies: The National Institute of Health (NIH) is collaborating with 12 biopharmaceutical companies, multiple research foundations, philanthropies, and the Foundation for the NIH, to develop a new program under the Cancer Moonshot, the Partnership for Accelerating Cancer Therapies (PACT). PACT will fund pre-competitive cancer research and share broadly all data generated for further research, ultimately bringing more new therapies to patients in less time. Potential initial focus areas include understanding responses to cancer therapies, clinical trial platforms for combination therapies, predictive modeling approaches, and therapies for rare cancers. Forging New Partnerships to Catalyze New Drug Discovery and Development: The Department of Energy (DOE), the National Cancer Institute (NCI), and GlaxoSmithKline are announcing a new public-private partnership designed to harness high-performance computing and diverse biological data to accelerate the drug discovery process and bring new cancer therapies from target to first in human trials in under one year. This partnership will bring together scientists from multiple disciplines to advance our understanding of cancer by finding patterns in vast and complex datasets to accelerate the development of new cancer therapies. Improving Patient Access to Medications and Information: The FDA is scaling up its efforts to provide accessible and time-saving information for physicians and patients pursuing expanded access requests for investigational drug treatments in cases of serious or life-threatening conditions. Most recently the agency published three new guidances, including one focused on reducing the time it takes for physicians to make expanded access requests. The FDA is also accelerating its efforts, including discussions with external parties, to establish a "Navigator" program to serve as a connection point between patients, providers, and drug developers to facilitate expanded access requests. New Federal Incentives for Coordinated Cancer Care: Today the Centers for Medicare and Medicaid Services (CMS) is announcing the enrollment of nearly 200 participating physician practices including more than 3,200 oncologists in its Oncology Care Model, a multi-payer model focused on incentivizing high quality, high value, patient-focused cancer care. Participants constitute a geographically, clinically, and organizationally diverse group of practices providing roughly $6 billion in care for an estimated 155,000 beneficiaries per year during the five year model who have committed to providing enhanced services to Medicare beneficiaries such as care coordination and navigation. These practices also agree to use national treatment guidelines for care and CMS will supply practice feedback data for continuous care improvement. Tri-Agency Coalition to Enhance Cancer Care – Applied Proteogenomics OrganizationaL Learning and Outcomes (APOLLO) Consortium: The Department of Defense (DoD), the Department of Veterans Affairs (VA), and the National Cancer Institute (NCI) are forming a new collaboration using state-of-the-art research methods in proteogenomics to more rapidly identify unique targets and pathways of cancer for detection and intervention. These methods will look at a patient’s genes that may lead to cancer and the expression of these genes in the form of proteins, with potential impact on disease formation and treatment for cancer patients. Initial collaborative efforts will focus on a cohort of 8,000 lung cancer patients within the nation's two largest healthcare systems and will make data broadly available to the research community. Ultimately the effort will be expanded to additional cancer types to reach more cancer patients within the VA and DoD, providing knowledge scalable for physicians across the country treating the more than 1.6 million new patients diagnosed with cancer each year. Private Sector Commitments in Response to the Vice President’s Call to Action Efforts are being mobilized throughout the country, and many motivated individuals and organizations have made important commitments in response to the Vice President’s call to action for the Cancer Moonshot, including: Alex’s Lemonade Stand Foundation: Alex's Lemonade Stand Foundation (ALSF) is committed to doubling its investment in childhood cancer research projects and family services by investing $150 million over the next five years. Additionally, ALSF will harness the power of big data by launching a bioinformatics lab to analyze and interpret pediatric cancer data to accelerate the pace of cures. ALSF raises money and awareness for childhood cancer causes, primarily research into new treatments and cures, and encourages and empowers others, especially children to get involved and make a difference. Kids and their families, businesses, and other supporters do a simple action - hold a lemonade stand - to support the cause, among other ways. American Cancer Society: The American Cancer Society (ACS) is the largest private, not for profit funder of cancer research in the United States and is committing to a goal of doubling its current research budget over the next five years. ACS currently spends approximately $100 million per year in new grants at academic research institutions across the country and another $15 to $20 million annually in its own intramural research in cancer epidemiology, surveillance and health services, behavioral research, and economics and health policy. ACS research programs are comprehensive across all aspects of cutting-edge cancer research. Since 1946, ACS has spent more than $4.5 billion to find cancer cures and forty-seven ACS-funded researchers been awarded the Nobel Prize. American Society of Hematology Multiple Myeloma Data Sharing Platform: As part of the American Society of Hematology’s (ASH) mission to help hematologists conquer blood diseases worldwide, ASH commits to develop an international Multiple Myeloma Data Sharing Platform. The Society recently convened stakeholders to discuss the feasibility of sharing multiple myeloma data. Based on the premise that accurate genomic data linked to clinical features would advance curative strategies and personalized medicine, ASH and its partners believe that through collaboration, sharing and pooling myeloma data over time would be an invaluable resource to caregivers, patients, researchers, and others in developing and delivering the promise of targeted therapy. The group will design and/or identify an existing data platform for sharing the data and supporting data analysis by various users. This multiple myeloma data sharing concept could be an example of what can be done in all cancers. Those collaborating with ASH include the Multiple Myeloma Research Foundation, the Mayo Clinic, the Dana Farber Cancer Institute, the University of Arkansas Myeloma Institute, and international partners in the United Kingdom, Spain, France, Germany, and the Netherlands. Breast Cancer Research Foundation: The Breast Cancer Research Foundation (BCRF), inspired by the Cancer Moonshot’s call for commitment, cooperation and collaboration, plans to double its annual cancer research investment from $50 million to $100 million by 2021, aiming for a cumulative investment of $1 billion. To accelerate the path from discovery to clinical implementation, BCRF will launch a multi-million-dollar impact-investment program to foster productive teams towards commercialization of potentially life-saving or paradigm-changing discoveries. Furthermore, BCRF intends to speed the “connecting of the dots” between the amassing of molecular information about cancer and the discovery of how those pieces fit together to cause the diseases called cancer. To accomplish this, BCRF will convene and support an academy of biologists, physicians, physicists, mathematicians, computer scientists, lay advocates, and other dedicated, creative individuals. CancerBase: Today, CancerBase, a grassroots collaboration of patients, scientists, and social media volunteers, will go live with a way to connect patients all around the world. Basic but critical information about most cancers and how they spread through the body just isn't readily available and CancerBase will work to solve this problem. With the potential of millions of patients coming together and anonymously contributing the what, when, and where of their cancers, CancerBase has the potential to empower patients and scientists to see cancer more clearly. For an intuitive sign-in experience, patients will be able to connect to CancerBase using Facebook Login, after which they can choose to answer questions about their diagnosis for anonymized inclusion in a global cancer map. Cancer Research UK: Scientists in the United States and the United Kingdom are teaming up to apply new cancer-cell detection technology to identify those patients whose cancer has returned after surgery or an initial response to treatment. Using a super-sensitive cell-scanning device, researchers will take a simple blood sample and not only identify early those patients whose cancer has returned but they will also be able to analyze the circulating tumor cells in great detail, providing new clues on how to treat the patient with the most effective therapy for their particular re-emerging cancer. As the technology is further refined and validated, the ambition is to apply the new methodology to detect cancer at its very earliest stages; in doing so, the aim is to markedly improve patient survival rates. The University of Southern California and Cancer Research UK Manchester Institute will build and operate identical laboratories with real-time sharing of research data and experimental procedures. Clinical studies will then be jointly designed and deployed to accelerate development and testing of this technology in the clinic, getting it to patients around the world as quickly as possible. The project is supported through a collaboration between the NCI-funded Kuhn-Laboratory at the University of Southern California and Cancer Research UK, which funds over $500 million each year. Cancer Support Community: On June 22, in alignment with the goals of the Cancer Moonshot, Cancer Support Community (CSC) launched the Frankly Speaking About Cancer Clinical Trials program, a landmark cancer education series devoted to dispelling common myths and building awareness among patients and caregivers about the importance of clinical trials as an option. CSC partnered with patients, caregivers, oncologists from academic and community settings, nurses, advocates, communicators, and industry partners to help bring a more targeted communications approach to the discussion. This robust research and conversation has helped inform the program through the eyes of the patient, which offers a new approach and new solutions including local and national workshops, interactive videos, webinars, a photo documentary, and a full suite of other patient-centric materials and resources to be rolled out throughout the remainder of this year that will reach 500,000 patients in 2016. As part of their commitment to reaching communities across the United States with the goals of the Cancer Moonshot, Cancer Support Communities is hosting 32 conversations on June 29th in 19 states. City of Miami Beach: As “the fun and sun capital of the world”, the City of Miami Beach is also deeply committed to reducing skin cancer. Through a collaboration with Destination Brands International (MB Suncare manufacturer) and Mount Sinai Medical Center, the City of Miami Beach provides dozens of free sunscreen dispensers on their beaches, parks, and public pools for residents and the millions who visit the area year-round. In response to the Vice President's call to action, Miami Beach is dedicated to continuing this program until at least 2021. Coding for Cancer: The Harvard Medical and Business Schools will design and execute prize-based challenges in cancer research to scale Coding for Cancer, a project initiated by the Laura and John Arnold Foundation. In collaboration with the Crowd Innovation Lab (CIL) at Harvard's Institute for Quantitative Social Science, the researchers will work with cancer-related foundations and the global oncology research community to identify computational bottlenecks in cancer research and design prize challenges to solve them. The collaboration will also simultaneously execute a prize challenge in a problematic area with a clear relation to cancer treatment and use this opportunity to train foundation science staff on the art and science of innovation contests. The results of the pilot grant will create a blueprint for action on the use of open innovation to accelerate scientific research in life sciences and develop a cohort of biomedical and multidisciplinary scientists that have experience with the design and execution of prize contests. Additionally, Sage Bionetworks, in partnership with the open science DREAM Challenges community and with support from the Laura and John Arnold Foundation, announces the official launch of the first of the Coding4Cancer (C4C) Challenges: the Digital Mammography DREAM Challenge. This $1.2 million prize competition will aim to improve the accuracy of digital-image breast cancer detection in order to improve patient outcomes and reduce healthcare costs. Challenge data will be contributed by Group Health Cooperative through the NCI-funded Breast Cancer Surveillance Consortium and by the Icahn School of Medicine at Mount Sinai. Cloud computing will be provided by Amazon Web Services and the IBM Watson Health Cloud. All competition results will be placed into the public domain, with the algorithms made available to researchers. Creative Commons: In response to the Vice President's call for open access to cancer research publications, Creative Commons will provide open educational resources, and tools that will support researchers, funders, medical professionals, and professors as they build open and collaborative communities for cancer research. These materials will include guides for adopting and implementing open licensing policies, training materials regarding working openly and using licensed materials and data, and technical tools for applying open licenses to shared works. As with all of Creative Commons's programs, these materials and tools will be freely available and openly licensed for all who need them, and can also be remixed and repurposed by anyone to serve each community's needs. Sharing all of our cancer resources ensures that the best materials and data are available to everyone, and increases the effectiveness and impact of the cancer community as a whole. Deloitte Consulting LLP and XPRIZE: Deloitte is designing an XPRIZE competition to generate breakthrough innovations for the prevention and eradication of cancer worldwide. Deloitte Consulting LLP is working alongside players across the cancer ecosystem, from governments to non-profit advocacy groups, and from research and development to health care delivery, to facilitate the development and improvement of cancer diagnosis, treatment, and care. XPRIZE, a non-profit organization, is the global leader in designing and implementing innovative competition models to help solve some of the world’s grandest challenges, including the $30 million Google Lunar XPRIZE and the $15 million Global Learning XPRIZE. DocGraph: DocGraph commits to creating and publicly releasing comprehensive analyses and data sets describing how Medicare patients travel through the health care system in the years before and immediately after their cancer diagnoses, including data about treating providers, procedures, diagnoses, medications, and survival, likely capturing almost 1 million Medicare cancer patients, as well as more than 10 million specific claim events. These analyses—based on Medicare claims data released as a result of the Obama Administration’s open data efforts—will reveal important differences in the experience of cancer patients based on factors such as geography, type of treating physicians and providers and treatment pathway. DocGraph will work with CareSet Systems to develop challenges to engage the data science community to derive additional insights and utility from these valuable data. Elsevier: Elsevier will create and make freely and publicly available a first-of-its kind benchmarking report detailing the current landscape of cancer research and collaborations in the United States. A clear and comprehensive view of the cancer research universe, the report will highlight which collaborations are working well and which ones could use improvement. Understanding this will provide a pathway to the most efficient discovery of new knowledge and its impactful clinical application, including how it will lead to the most promising outcomes with the power to help the greatest number of patients. IBM and The Department of Veterans Affairs: IBM and the Department of Veterans Affairs are launching a public-private partnership to help doctors scale access to precision medicine for 10,000 American veterans with cancer over the next two years. IBM will provide Watson for Genomics, which has been trained for genomic analysis, to scientists and pathologists that have sequenced DNA for VA cancer patients to help them identify the likely cancer-causing mutations and treatment options that target those specific mutations – a data-intensive process that has been time consuming and difficult to scale in the past. As America’s largest integrated health system, VA provides care to 3.5 percent of the nation’s cancer patients – the largest group of cancer patients in the country. Watson is expected to help VA clinicians give veterans rapid access to precision medicine options, particularly for patients with advanced cancer. The collaboration with VA is also expected to advance genomic research. Laura and John Arnold Foundation: The Laura and John Arnold Foundation (LJAF) has approved funding for a collaboration with the Global Alzheimer’s Platform (GAP), Health Care Services Corporation (HCSC), Medecision, PricewaterhouseCoopers (PwC), and Amida Technology Solutions to better connect cancer patients and Alzheimer's patients with clinical trials. The $300,000 grant by LJAF will be fully matched by GAP, and will support a twelve-month project to create an open-source, online platform that identifies and matches candidates to clinical trials. The platform will collect and connect data from patient registries, electronic medical and personal health records, pharmaceutical researchers, and clinical trial registries in a patient-centered, secure, Blue Button-based application. The objective is to dramatically accelerate and scale participant recruitment (based on an individual’s unique health profile), to clinical trials that will help researchers develop new treatments and increase patient access to those medicines. LIVESTRONG and YMCA of the USA: LIVESTRONG and YMCA of the USA commit over the next five years to: 1) scale LIVESTRONG at the YMCA to reach the milestone of serving 100,000 cancer survivors (more than doubling the number served to-date) and 2) integrate the program into clinical practice across the country. LIVESTRONG at the YMCA is an evidence-based physical activity program for cancer survivors that was created in 2007 and is currently offered in more than 500 communities across the U.S. at little to no cost for participants. The program has been shown to improve survivors’ overall quality of life, increase cardiovascular endurance, decrease cancer-related fatigue, and help them meet or exceed recommended amounts of physical activity. Massive Acceleration in Prevention Science: Milken Institute School of Public Health at the George Washington University (GWU) in collaboration with Case Comprehensive Cancer Center at Case Western Reserve University will develop community-wide programs to prevent cancer. The Massive Acceleration in Prevention Science (MAPS) collaboration aims to lower the smoking rates for at-risk populations that have higher incidences of undiagnosed lung cancer and prevent cervical and other cancers due to human papillomavirus (HPV). The program will use social media, mobile health, and a variety of technological interventions to enhance traditional approaches in order to reduce smoking and tobacco use in Washington, D.C. (population 672,228) and metropolitan Cleveland (population 3.9 million), both of which have higher than average smoking rates, especially in those cities' underserved communities. MAPS will aim to boost rates of HPV immunization via a combination of communications and policy efforts. Innovative approaches will include the use of communication technologies to narrowly tailor outreach and intervention efforts to the specific populations in our two regions. The program will make use of an open source data platform to aggregate longitudinal data on the determinants of health behaviors and use insights from analyses to design and optimize policies and interventions. Medscape/WebMD: WebMD and Medscape will conduct a joint survey of their audiences on attitudes and behaviors related to cancer prevention, and report on the findings by October 31, 2016. The survey will explore healthy lifestyle behaviors, use of cancer screening and prevention strategies, and communication practices among health care professionals and their patients around cancer prevention topics. WebMD and Medscape remain committed to raising awareness, informing and educating on the topics of cancer prevention, diagnosis, treatment and survivorship to their audience of consumers, patients, physicians, and healthcare professionals. Milken Institute FasterCures and The Department of Veterans Affairs: The Department of Veterans Affairs (VA) will host an event on Accelerated Precision Oncology Care in diagnostics and therapeutics for all VA Cancer Patients, convened by the Milken Institute FasterCures in Washington D.C. This event will bring together public and private partners; including leadership of major biopharmaceutical companies, significant U.S. philanthropists, prominent foundations, and many more. This effort will be pursuant to discussing and collaborating around the latest innovations in precision oncology, and activating a variety of approaches to fast-track pathways to cancer care and cures. National Brain Tumor Society: The National Brain Tumor Society (NBTS) is committing to the launch of a major engagement and education initiative to increase patient-centered drug development, with a particular emphasis on clinical trial participation among brain cancer patients. The objective of this initiative will be to improve brain cancer clinical trials and empower patients to be informed and active in the research and drug development process. As clinical trial participation in general is an area that the Cancer Moonshot Initiative has wisely chosen to include among its topics of discussion, NBTS is inspired to commit to leading a dedicated effort that will ultimately enhance access to, and improve the quality of, brain cancer clinical trials. This initiative will aim to advance drug development efforts across the neuro-oncology clinical trial landscape - including NBTS' collaborative programs with clinical research components - creating systematic change in the field's ability to fast-track clinical development of the most promising emerging brain cancer therapeutics. National Photonics Initiative: The National Photonics Initiative (NPI) will coordinate new, high-level public and private collaborations to develop a cancer technology road map that identifies the most promising existing and new technologies for increased and concerted private and public investment that will accelerate the early detection of cancer, saving lives and improving the quality of health care within the next five years. The NPI is bringing together the scientific community, leading medical technology industry, over 350 hospitals and major patient advocacy groups across the nation to leverage the more than $3 billion annual private investments in cancer research toward early detection technologies of the most aggressive cancers. OneSource: The University of California Office of the President, University of California Health, the Athena Breast Health Network, Quantum Leap Healthcare Collaborative, and Salesforce commit to establishing a new transformative model for health care delivery that evolves the point of care into a patient-centric data hub. By introducing the use of standard “OneSource” checklists for cancer care documentation, and enabling feedback, and multiple connections to registries, trials, and research, we will create a patient centric data hub. The systems of care and research can be integrated, accelerating learning and driving efficiency and healthcare value. This new model has evolved from our experience personalizing screening and prevention for over 100,000 breast cancer patients in the Athena Breast Health Network and the launch of the PCORI funded Wisdom study); seamless connection to real-time clinical trial registries (CT match/Veterans Affairs and breastcancertrials.org) and adapting care through trials (I-SPY, 20 clinical sites). In the same way data aggregation has transformed such industries as communications, retail, and financial services, the intelligent application of patient clinical trial data will be a disruptive technology that drives the personalization of cancer medicine. PatientCrossroads and DNAnexus: PatientCrossroads and DNAnexus as part of the Cancer Moonshot Summit are announcing a partnership on the Integrated Data Engagement Analytics (IDEA) platform - to facilitate patient consented sharing of genetic, proteomic, and electronic health records (EHR)/phenotypic data to accelerate disease research. This pioneering program leverages the rights of patients to request their raw genetic testing files, proteomic data, and electronic medical records and to share this rich data in the IDEA platform for deep analysis. PCORnet: Today, PCORnet, the National Patient-Centered Clinical Research Network, announces the creation of a planning group, composed of patients, clinicians, and investigators that will work together within PCORnet to 1) identify and prioritize our nation's top cancer research questions; 2) develop approaches for using real-world electronic data to address unmet research needs in prevention, diagnosis, and treatment of cancer; and 3) reduce disparities in cancer care and outcomes. This planning group will seek funding from PCORI to establish a formal PCORnet Cancer Collaborative Research Group (CRG) by October 1. Additionally, this planning group commits to partnership and collaboration with other sponsors of real-world clinical data collection and analysis to harmonize cancer-related data from diverse electronic health record (EHR) systems for use in large, collaborative research and quality improvement programs. PCORnet's Cancer CRG will build on PCORnet's experience as a national clinical research enterprise based on standardized EHR, and clinical and patient-reported data from more than 100,000,000 people. Prostate Cancer Foundation and The Department of Veterans Affairs: The Prostate Cancer Foundation (PCF) will donate a minimum of $50 million dollars to precision oncology research over the next 5 years with an emphasis on supporting prostate cancer research and care for veterans. The Department of Veterans Affairs (VA) and PCF will partner to build a consortium of thought leaders from VA, the National Cancer Institute (NCI), PCF, and others to: 1) develop a 5-year strategic plan to help implement and augment precision medicine for the treatment of prostate cancer among veterans; and 2) fund a series of pilots across the country to accelerate precision oncology, clinical research, and the clinical care of veterans with prostate cancer using the latest and most sophisticated biotechnologies. These biotechnologies include proteogenomics in liquid biopsies and deployment of supercomputing for “precision prescriptions.” Syapse: Intermountain Healthcare, Stanford Cancer Institute, Providence Health & Services, Catholic Health Initiative, Henry Ford Health System, and Syapse have joined together to launch OPeN, the Oncology Precision Network. OPeN will advance cancer care through sharing of cancer genomics data, rapidly bringing the most promising treatment insights to cancer patients and physicians with the potential of increasing access to clinical trials. With its current membership, OPeN comprises data and physicians across 11 states, 79 hospitals and 800 clinics, and will impact 50,000 new cancer cases per year. OPeN pledges to expand its impact across the United States by onboarding at least five new healthcare systems in the next 12 months, focusing on community healthcare systems outside of the currently-served states in order to bring the best quality cancer care to patients in other geographic regions. OPeN pledges to facilitate data access to help providers guide treatment decisions as soon as the first comprehensive data set is available, enabling a broader community of providers to leverage this new knowledge and drive more rapid progress. OPeN pledges to bring the best cancer care to patients where they live by making clinical trials more readily available in the community. OPeN will increase access to clinical trials by matching patients from at least 20 community sites across the network to appropriate trials within 15 months.

Monday, March 7, 2016

President #Obama Legacy - The President Obama Legacy - The President Who Developed A Breast Cancer Cure:


Barron's Medical Journal Reporting From South By South West Festival Austin, Texas USA AUSTIN, Texas ( AP ) ---- President Obama Legacy Is The President Who Developed A Breast Cancer Cure. Yes Under the Obama Presidency Genomics Science has found the path to a Breast Cancer Cure. CRISPR/Cas System Invented BY Jennifer Doudna & Genomics is a winner. . — As a child in Hilo, one of the less touristy parts of Hawaii, Jennifer A. Doudna felt out of place. She had blond hair and blue eyes, and she was taller than the other kids, who were mostly of Polynesian and Asian descent.

“I think to them I looked like a freak,” she recently recalled. “And I felt like a freak.” Her isolation contributed to a kind of bookishness that propelled her toward science. Her upbringing “toughened her up,” said her husband, Jamie Cate. “She can handle a lot of pressure.” These days, that talent is being put to the test.

Three years ago, Dr. Doudna, a biochemist at the University of California, Berkeley, helped make one of the most monumental discoveries in biology: a relatively easy way to alter any organism’s DNA, just as a computer user can edit a word in a document.

The discovery has turned Dr. Doudna (the first syllable rhymes with loud) into a celebrity of sorts, the recipient of numerous accolades and prizes. The so-called Crispr-Cas9 genome editing technique is already widely used in laboratory studies, and scientists hope it may one day help rewrite flawed genes in people, opening tremendous new possibilities for treating, even curing, diseases. But now Dr. Doudna, 51, is battling on two fronts to control what she helped create. While everyone welcomes Crispr-Cas9 as a strategy to treat disease, many scientists are worried that it could also be used to alter genes in human embryos, sperm or eggs in ways that can be passed from generation to generation. The prospect raises fears of a dystopian future in which scientists create an elite population of designer babies with enhanced intelligence, beauty or other traits. Scientists in China reported last month that they had already used the technique in an attempt to change genes in human embryos, though on defective embryos and without real success.

In April 2015 a team of Chinese scientists reported in a little known journal, Protein & Cell, the use of CRISPR/Cas9 to cleave and then repair the HBB gene in nonviable human embryos. The mutated form of HBB causes B-thalassemia, a potentially fatal blood disease. To say the experiment prompted controversy is an understatement. It was published on the heels of two high-profile commentaries in Nature and Science, both of which urged caution about using CRISPR/Cas9 and other technologies to edit the human germline; the Nature authors went so far as to recommend a stop of experiments precisely like the one reported in Protein & Cell. The Liang et al. paper seemed to fly in the face of the recommendations. Though the researchers used triponuclear human embryos (an essential fact missed by some of the breathless reporting in the days after), they designed the experiment as a test of a possible therapeutic strategy. If eventually proven safe, a diseased embryo would be corrected using CRISPR/Cas9 with the intent of eventually making a healthy baby. Importantly, the authors reported notable off-target effects of CRISPR-based gene editing, low efficiency of homologous recombination directed repair (HDR), mosaicism, and unwanted mutations. They concluded: Taken together, our data underscore the need to more comprehensively understand the mechanisms of CRISPR/Cas9-mediated genome editing in human cells, and support the notion that clinical applications of the CRISPR/Cas9 system may be premature at this stage. 

Further Genomics Research:

Genomcis and LC (liquid Chromatography) -MS/MS (Tandem Mass) mass spectrometry analysis is What’s Next For A Breast Cancer Cure. Barron Medical Journal has found we now have the know how and the systems to detect breast cancer genes and now at this year’s show BMJ has found one of the major advances in science that have been around for over a Hundred years MS mass Spectrometry (MS) is an analytical technique that produces spectra (singular spectrum) of the masses of the molecules comprising a sample of material. The great news about MS is we can now validate our genomic gene finding. The next step is to get this technology out of the University

centers in to commercial use. Here are some success stories on breast cancer and MS Mass Spectrometry. Barron’s Medical Journal breast cancer focus was amplified right outside of Washington, DC USA Where The National Institute Of Health Director Francis Collins gave the rights and say so of one of the most important genes in the fight for breast cancer. The HSP70 the gene protein cancer cells kept alive…..More on the background for Henrietta Lacks in the next paragraph. Tumor differentiation factor (TDF) is our line of discussion in this article. We now have genomics which tells us that genes GRP78 and HSP70 are key in Indentifying and solving breast cancer. In molecular genomics we also have a tool called Mass spectrometry which allows scientist to verify our gene analysis.

In others words cancer cells taken without consent from A African American Women is used to identify bio Markers used in the scientific puzzle "A Breast Cancer Cure". Henrietta Lacks (August 1, 1920 – October 4, 1951) (sometimes erroneously called Henrietta Lakes, Helen Lane or Helen Larson) was an African-American woman who was the unwitting source of cells (from her cancerous tumor) which were cultured by George Otto Gey to create an immortal cell line for medical research. This is now known as the HeLa cell line. On January 29, 1951, Henrietta went to Johns Hopkins Hospital because she felt a knot inside her. It all started when she asked her cousins to feel her belly, asking if they felt the lump that she did. Her cousins assumed correctly that she was pregnant. But, after giving birth to her fifth child, Joseph, Henrietta started bleeding abnormally and profusely. Her local doctor tested her for syphilis, which came back negative, and referred her to Johns Hopkins.

Johns Hopkins was their only choice for a hospital, since it was the only one in proximity to them that treated black patients. Howard Jones, her new doctor, examined Henrietta and the lump in her cervix. It was like nothing he had ever seen before. He cut off a small part of the tumor and sent it to the pathology lab. Soon after, Jones discovered she had a malignant epidermoid carcinoma of the cervix Stage 1 (cervical cancer). Lacks was treated with radium tube inserts, which were sewn in place. After several days in place, the tubes were removed and she was released from Johns Hopkins with instructions to return for X-ray treatments as a follow-up. During her radiation treatments for the tumor, two samples of Henrietta's cervix were removed— a healthy part and a cancerous part— without her permission.[10] The cells from her cervix were given to Dr. George Otto Gey. These cells would eventually become the HeLa immortal cell line, a commonly used cell line in biomedical research.

In significant pain and without improvement, Lacks returned to Hopkins on August 8th for a treatment session, but asked to be admitted. She remained at the hospital until the day of her death. Though she received treatment and blood transfusions, she died of uremic poisoning on October 4, 1951 at the age of thirty-one. A subsequent partial autopsy showed that the cancer had metastasized throughout her entire body. Henrietta Lacks was buried without a tombstone in a family cemetery in Lackstown, a part of Clover in Halifax County, Virginia. Her exact burial location is not known, although the family believes it is within feet of her mother's gravesite. Lackstown is the name of the land that has been held by the (black) Lacks family since they received it from the (white) Lacks family, who had owned the ancestors of the black Lackses when slavery was legal. Many members of the black Lacks family were also descended from the white Lacks family. A row of boxwoods separates the graves of whites from those of the blacks buried in the family cemetery.For decades, Henrietta Lacks' mother had the only tombstone of the five graves in the family cemetery in Lackstown, and Henrietta's own grave was unmarked. [11][12] In 2010, however, Dr. Roland Pattillo of the Morehouse School of Medicine donated a headstone for Lacks after reading The Immortal Life of Henrietta Lacks. The headstone, which is shaped like a book, reads: Henrietta Lacks, August 01, 1920-October 04, 1951. In loving memory of a phenomenal woman, wife and mother who touched the lives of many. Here lies Henrietta Lacks (HeLa). Her immortal cells will continue to help mankind forever. Eternal Love and Admiration, From Your Family The cells from Henrietta's tumor were given to researcher George Gey, who "discovered that [Henrietta's] cells did something they'd never seen before: They could be kept alive and grow." Before this, cells cultured from other cells would only survive for a few days. Scientists spent more time trying to keep the cells alive than performing actual research on the cells but some cells from Lacks's tumor sample behaved differently than others. George Gey was able to isolate one specific cell, multiply it, and start a cell line. Gey named the sample HeLa, after the initial letters of Henrietta Lacks' name. As the first human cells grown in a lab that were "immortal" (they do not die after a few cell divisions), they could be used for conducting many experiments. This represented an enormous boon to medical and biological research. HeLa by a researcher at the hospital helped answer the demands of the 10,000 who marched for a cure to polio shortly before Lacks' death. By 1954, the HeLa strain of cells was being used by Jonas Salk to develop a vaccine for polio To test Salk's new vaccine, the cells were

In the avalanche of commentary that followed was a blink-and-you-missed-it defense of the decision to publish the paper by Xiaoxue Zhang (2014), the editor of Protein & Cell. The editorial is a fascinating read, encapsulating the social and ethical tensions surrounding germline editing. Perhaps stung by criticism the experiment was unethical , Zhang says, “With extraordinary care, consideration and deliberation, Protein & Cell has decided to publish in this issue a scientific study that reports CRISPR-based gene-editing of human tripronuclear zygotes.” Zhang goes on to justify why the research was published in the first place: The editorial decision to publish this study should not be viewed as an endorsement of this practice nor an encouragement of similar attempts, but rather the sounding of an alarm to draw immediate attention to the urgent need to rein in applications of gene-editing technologies, especially in the human germ cells or embryos. 

From an ethics and policy perspective, how should we measure the Protein & Cell experiment and the decision to publish it? A framework for social responsibility such as the model proposed by Sankar and Cho in their target article might help, but would likely need to include more stakeholders than just bench scientists. Decisions to publish do not occur in isolation. Researchers, reviewers, ethics advisors, and editorial boards all have an opportunity to dialogue during the review process, so the responsibilities to publish socially controversial research are shared. In her commentary, Bovenkirk argues for a “thick” accounting of social responsibility in the sciences and this seems to make sense here. With respect to the Protein & Cell publications, it appears that important elements of the Sankar and Cho framework are already in play. Categories of justification, reasoning to identify harms and benefits, reflexivity, and timing—specifically, designing an experiment ostensibly to uncover the risks the authors enumerate in the conclusions—are on full view in both the research paper and in the editor’s justification. Of course we must trust that other stakeholders were part of the “extraordinary care, consideration and deliberation” and that those deliberations would be fully available to outside observers. But there is a nuance about the Protein & Cell example that is worth a closer look. In their commentary, Mertes and Penning argue that because the Liang et al research showed the dangers of any clinical use of the technology, an outcry about whether the research should have been published is misplaced. After all, both the Science and Nature essays called for more research to determine the safety and efficacy of CRISPR/Cas9 for future clinical use. Wasn’t this precisely what the experts ordered?

It would seem so. But an argument could be made—something hinted at but not directly addressed in Greeley and Charo’s lighthearted target article—that the Chinese experiment was frivolous. The results in the Protein & Cell study were anticipated in animal studies and indeed predicted by the Nature commentary. Some CRISPR/Cas9 researchers believe that the experiment provided little scientific insight. The raises the question of whether we should publish the technical feat of human germline editing or work that moves the field forward in significant ways. So what do we do now that the Protein & Cell study is out? Follow-on experiments become increasingly derivative and are worth exponentially less to science. At what point do such experiments become data-gathering exercises rather than answers to fundamental questions about human development and disease? Given the controversial nature of human germline research, what experiments investigating disease type, embryo stage, culture conditions and other incremental advances should go forward? For example, gene-editing technologies can either knock out (cleave a gene of interest) or knock in (insert a gene of interest). The Liang and colleagues experiment was technically a knock out study. The researchers edited the HBB gene and then asked whether genetic repair pathways recruited an endogenous gene, HBD, to replace the cleaved sequence. Suppose the next CRISPR/Cas9 experiment using human embryos attempts a knock in or gene replacement strategy. Does this represent a frivolous or an important use of the technology? There are some pathways to take with respect to this question. In a recent commentary in Nature Biotechnology, we offer examples of in vitro research that is ethically and scientifically justified, such as probing questions of early human development and infertility. Such research is covered under existing oversight mechanisms and regulation.

Tuesday, January 12, 2016

President Obama Legacy Will Include A Breast Cancer Cure


Barron's Medical Journal Medical and Science Reporter reporting from JP Morgan Chase Medical Conference San Fransisco CA USA San Francisco ( AP ) -- President Obama Legacy Will Include A Cure For Breast Cancer. In The last State Of The Union Address Given in the year 2016 Barron's Medical Journal has declared A Breast Cancer Cure is On The Eight Yard Line. The Obama administration has watched over information technology using Genomics. Today Genomics Science at The JP Morgan Chase Medical Conference has Introduced new " Game Changing " technology from Illumina. Illumina, the $25 billion maker of gene sequencing technology, has created a new company that's trying to invent a blood test to identify all cancers in their early stages, something that would be a tremendous help in diagnosing the illness before it is too difficult to treat effectively. The team behind the announcement is not the first to attempt something of this nature, and previous efforts by other companies have been criticized for having too little research behind them or focusing too much on detection rather than treatment. Crucially, this blood test does not exist yet, and while scientists will be working furiously to try to make it happen, it doesn't mean they will succeed. But this latest bet is one of the best-funded, with a number of illustrious scientists already involved — and Illumina's backing may give it a critical boost. The new company, called Grail (as in, it's trying to achieve something considered the Holy Grail for cancer researchers) hopes to have a pan-cancer blood test by 2019, an extremely ambitious goal. That would mean that anyone could add such a test onto their annual physical — no need for separate tests for different types of lung cancer, prostate cancer, or any other form of the illness. Breast Cancer Patients Quality Of Life Has Just Been In Proved

Saturday, October 10, 2015

The New Weapon To Fight Breast Cancer: A ( Breast Cancer Month Special Report)


Robert-Barron Graham Reporting For Barron’s Medical Journal Reporting From Rice University, Houston, Texas USA.

Brought To You By Woodlands Fashion: The New Weapon To Fight Breast Cancer: A ( Breast Cancer Month Special Report) – The Winner Is: TP53 And Noninherited (Somatic) Mutations .


Houston ( AP ) -- Its Breast Cancer Month, Barron’s Medical Journal love to see all of the organizations and individuals coming together to end breast cancer. Our sister division BMJSports reports 100% of the NFL Teams in the United States will wear pink apparel. Houston's Own Carolyn Farb Who's Giving to so many causes including Breast Cancer and The Community Artists' Collective. One must think With all of the effort and inference to October as Breast Cancer Month, We would like to offer a Report Card on what is The Best Science has to offer in A Cure. A 2015 Answer which addresses this awful disease.

The breast cancer buzz is The ( TP53 ) What is the official name of the TP53 gene? The official name of this gene is “tumor protein p53.”

Brought To You By American Apparel :

TP53 is the gene's official symbol. The TP53. The TP53 gene provides instructions for making a protein called tumor protein p53 (or p53). This protein acts as a tumor suppressor, which means that it regulates cell division by keeping cells from growing and dividing too fast or in an uncontrolled way.

The p53 protein is located in the nucleus of cells throughout the body, where it attaches (binds) directly to DNA. When the DNA in a cell becomes damaged by agents such as toxic chemicals, radiation, or ultraviolet (UV) rays from sunlight, this protein plays a critical role in determining whether the DNA will be repaired or the damaged cell will self-destruct (undergo apoptosis). If the DNA can be repaired, p53 activates other genes to fix the damage. If the DNA cannot be repaired, this protein prevents the cell from dividing and signals it to undergo apoptosis. By stopping cells with mutated or damaged DNA from dividing, p53 helps prevent the development of tumors. Because p53 is essential for regulating cell division and preventing tumor formation, it has been nicknamed the "guardian of the genome."

Noninherited (somatic) mutations in the TP53 gene are much more common than inherited mutations, occurring in 20 to 40 percent of all breast cancers. These somatic mutations are acquired during a person's lifetime and are present only in cells that become cancerous. The cancers associated with somatic mutations do not occur as part of a cancer syndrome. Most of these mutations change single protein building blocks (amino acids) in the p53 protein, which reduces or eliminates the protein's tumor suppressor function. Because the altered protein is less able to regulate cell growth and division, DNA damage can accumulate. This damage may contribute to the development of a cancerous tumor by allowing cells to grow and divide in an uncontrolled way. polygenic trait is one whose phenotype is influenced by more than one gene. Traits that display a continuous distribution, such as height or skin color,

A single nucleotide polymorphism, also known as simple nucleotide polymorphism, (SNP, pronounced snip; plural snips) is a DNA sequence variation occurring commonly within a population (e.g. 1%) in which a single nucleotide — A, T, C or G — in the genome (or other shared sequence) differs between members of a biological

Brought To You By Fashion Woodlands

Germline mutations in the TP53 gene are associated with Li-Fraumeni syndrome (LFS), a rare inherited cancer predisposition syndrome that significantly increases a person’s risk of developing breast cancer and many other types of cancer. LFS affects between one in 5,000 and one in 20,000 people. People with LFS have up to a 50% risk of developing cancer by age 30, and up to a 93% chance of developing cancer in their lifetime. Breast cancer is the most common cancer diagnosed in women with a TP53gene mutation. Most individuals with LFS inherited the TP53 mutation from a parent, though an estimated 7-20% are the first in their family to have a TP53 gene mutation.

“These findings suggest that we have been identifying only the most clinically affected LFS families, and raises the concern that we have overestimated cancer risks for them,” said Judy Garber, MD, MPH, Director, Center for Cancer Genetics and Prevention, Dana Farber Cancer Institute in Boston, and one of the study’s authors. “The findings make the collection and analysis of unselected data more important than ever, and the kind of data that panels can provide essential to that work.” For the study, researchers reviewed data from 25,182 patients that underwent TP53testing conducted at Ambry. Among those positive for a TP53 mutation, personal and family cancer histories were examined to identify specific patterns and to determine whether any National Comprehensive Cancer Network (NCCN) testing criteria were met, including Classic criteria, Chompret criteria, and breast cancer diagnosis before age 36 years.

In total, 187 patients (0.74%) tested positive for TP53 mutations. These results came from single gene testing (118/2956, 3.99%) and from MGPT (69/22,226, 0.31%). Of all those tested, 95% who underwent single gene testing (SGT) had a cancer diagnosis, versus 82% of patients who had MGPT.

A Cool software --canEvolve that will be based on cloud computing. Cloud computing can accelerate the processing time by providing on-demand resources for queries and Hadoop-based distributed computing for running analysis. Currently we are redesigning some of the processing and visualization pipelines to use R with the Hadoop framework. The next version of canEvolve will better integrate regulatory and protein-protein interaction information. It will also allow researchers to analyze their own datasets in light of current knowledge, stored analysis results and state-of-the-art methodologies available at the portal in the form of automated workflows.

Neurogenesis and Epidermal Growth Factor Receptor genes can partner with , Genomics and President Obama Brain Acivity Mapping all working hand in hand will look for tumors identified recurrent genomic aberrations in each molecular subtype. The classical subtype was characterised by frequent EGFR amplification and EGFRvIII mutations, CDKN2A deletion, and a lack of TP53mutations, whereas the mesenchymal subtype was characterised by NF1, TP53, and PTEN mutations. Consensus neuropathological review of a subset of TCGA cases has shown that the proneural, classical, and mesenchymal subtypes are enriched for GBM with oligodendroglial features, small-cell GBM, and gliosarcoma (a morphological variant of GBM with mesenchymal differentiation (Miller and Perry, 2007)), respectively (Cameron Brennan, personal communication). Moreover, pseudopalisading necrosis and to a lesser extent florid microvascular proliferation are frequent in mesenchymal GBM, but the proneural subtype typically lacks necrosis. These findings suggest that mesenchymal GBM may be uniquely susceptible to angiogenesis inhibitors, a hypothesis currently being tested in the RTOG 0825 trial discussed below. The proneural subtype, which like previous studies (Phillips et al, 2006; Lee et al, 2008) was found in younger patients, harboured frequent PDGFRAamplification and mutations in IDH1, TP53, andPIK3CA/PIK3R1, suggesting susceptibility to PDGFRA- and PI3K-targeted therapies. A recent proteomic analysis confirmed protein- and phosphorylation-level signalling abnormalities in the EGFR, PDGFR, and NF1 pathways in classical, proneural, and mesenchymal subtypes of GBM, respectively, further suggesting that these GBM subtypes may be uniquely susceptible to targeted agents (Brennan et al, 2009). It is a great day for Science and News organization around The World