Barron's Medical Journal: May 2012

Tuesday, May 29, 2012

Should The Science, Technology, Engineering, and Mathematics (STEM)Stay in the United States After Graduating From American Universities

Robert Graham Ph.D. and Hybrid Medical Media Reporting from The NAFSA 2012

"Association of International Educators" Annual Conference & Expo in Houston, Texas, May 28, 2012-------

Should The Science, Technology, Engineering, and Mathematics (STEM)Stay in the United States After Graduating From American Universities

A Interview with The CEO Of Gennxeix Biotech Inc Selene Flores A Houston Base Genomics Science Company and Flores says Yes One Of The Area That would benefit the most is Breast Cancer. Flores says approximately 30% of malignant breast cancers

demonstrate overamplification of the human epidermal receptor type 2 (HER2) gene. HER-2 can be resistant to low-doses of anthracycline-based Hybrid Pharma have demonstrated that they can be used to map DNase (deoxyribonuclease) DNA origins of

replication. Hybrid Pharma Recent progress in microarray technology has been related to the development of high resolution microarrays which can map genomic alterations and constitutional variants in DNA copy number at an extremely high resolution for Cancer chemotherapy. formalin fixed, paraffin embedded techniques and Her-2 The Good News is that science has advanced. Sections of microarray provide targets for parallel in situ detection of DNA, RNA and protein targets in each specimen on the array. The better News is that Genomics is on the Clock. Genomics provide a faster cheaper more effective way to detect the Her2 gene by using Semiconductor Sequencing. A example of this technique is Hybrid Pharma Semiconductor Sequencing. "Quantum Theory" In Action for Breast Cancer Patients. A polymerase is an enzyme whose central function is associated with polymers of nucleic acids such as RNA and DNA. The primary function of a polymerase is the polymerization of new DNA or RNA against an existing DNA or RNA template in the

processes of replication and transcription. In association with a Hybrid Pharma also uses a Visualize Real-Time Breast Cancer Data using Signal Stochastic Resonance Units Neurons Detection and Analysis for Breast Cancer model after McCulloch-Pitts. Hybrid Pharma computer-assisted diagnosing of breast cancer from mammograms. Hybrid Pharma works is a genetic network simulation trained with tumor incidence data from knockout experiments. Gennxeix Biotech uses Semiconductor Sequencing Chips that create a direct connection between Biochemical and digital information, bringing these two languages together. Hybrid's chips are designed like any other semiconductor chips. Pairing proprietary semiconductor technology with sequencing chemistry a nucleotide is incorporated into a strand of DNA by a polymerase, a hydrogen ion is released. Gennxeix Biotech used a high-density array of micro-machined wells for bioctechnology process in a massive way. Each well holds a different DNA template. Beneath the wells is an ion-sensitive layer and beneath that a proprietary Ion sensor. HER2 in many patients respond differently. Genomics can be the GPS to Extend life in Breast Cancer Patients. formalin fixed, paraffin embedded techniques and Her-2 Approximately Where do you really come from? And how can this information Solve Breast Cancer? Approximately 30% of malignant breast cancers demonstrate overamplification of the human epidermal receptor type 2 (HER2) gene. HER-2 can be resistant to low-doses of anthracycline-based Hybrid Pharma have demonstrated that they can be used to map DNase (deoxyribonuclease) DNA origins of replication. Hybrid Pharma Recent progress in microarray technology has been related to the development of high resolution microarrays which can map genomic alterations and constitutional variants in DNA copy number at an extremely high resolution for Breast Cancer chemotherapy. formalin fixed, paraffin embedded techniques and Her-2The Good News is that science has advanced. Sections of microarray provide targets for parallel in situ detection of DNA, RNA and protein targets in each specimen on the array. The better News is that Genomics is on the Clock. Genomics provide a faster cheaper more effective way to detect the Her2 gene by using Semiconductor Sequencing. A example of this technique is Hybrid Pharma Semiconductor Sequencing. "Quantum Theory" In Action for Breast Cancer Patients. A polymerase is an enzyme whose central function is associated with polymers of nucleic acids such as RNA and DNA. The primary function of a polymerase is the polymerization of new DNA or RNA against an existing DNA ohttp://www.blogger.com/img/blank.gifr RNA template in the processes of replication and transcription. In association with a Hybrid Pharma also uses a Visualize Real-Time Breast Cancer Data using Signal Stochastic Resonance Units Neurons Detection and Analysis for Breast Cancer model after McCulloch-Pitts. Hybrid Pharma computer-assisted diagnosing of breast cancer from mammograms. Hybrid Pharma works is a genetic network simulation trained with tumor incidence data from knockout experiments. Gennxeix Biotech uses Semiconductor Sequencing Chips that create a direct connection between Biochemical and digital information, bringing these two languages together. Hybrid's chips are designed like any other semiconductor chips. Pairing proprietary semiconductor technology with sequencing chemistry a nucleotide is incorporated into a strand of DNA by a polymerase, a hydrogen ion is released. Gennxeix Biotech used a high-density array of micro-machined wells for bioctechnology process in a massive way. Each well holds a different DNA template. Beneath the wells is an ion-sensitive layer and beneath that a proprietary Ion sensor. HER2 in many patients respond differently. Genomics can be the GPS to Extend life in Breast Cancer Patients.

Saturday, May 26, 2012

GenNXeix Biotech Honoring Francis Collins of CEO of NIH

HOUSTON, May 24/PRNewswire/ — GenNXeix Biotech Software is one of the leading supporters of Genomics Science Black Tie Ball to take place October 20, 2012 at the Hotel ZA ZA in Houston. Honoring Francis Collins of CEO of NIH for his years of working with Genomics. An Example

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of his work is the ambitious national plan to fight Alzheimer’s disease. The plan was called for in the National Alzheimer’s Project Act (NAPA), which President Obama signed into law in January 2011. The National Plan to Address Alzheimer’s Disease sets forth five goals, including the development of effective prevention and treatment approaches for Alzheimer’s disease and related dementias by 2025. In February 2012, the administration announced that it would take immediate action to implement parts of the plan, including making additional funding available in fiscal year 2012 to support research, provider education and public awareness. Today, the Secretary announced additional specific actions, including the funding of two major clinical trials, jumpstarted by the National Institutes of Health’s (NIH) infusion of additional FY 2012 funds directed at Alzheimer’s disease; the development of new high-quality, up-to-date training and information for our nation’s clinicians; and a new public education campaign and website to help families and caregivers find the services and support they need. GenNXeix Event Coordinator To help accelerate this urgent work, the President’s proposed FY 2013 budget provides a $100 million increase for efforts to combat

Alzheimer’s disease. These funds will support additional research ($80 million), improve public awareness of the disease ($4.2 million), support provider education programs ($4.0 million), invest in caregiver support ($10.5 million), and improve data collection ($1.3 million). This and many other examples is why GenNXeix Biotech is Honoring Francis Collins. Proceeds from the event will support American Cancer Society, to initiate the development and deployment of promising new Genomics Science and therapies to improve and save patient lives. The celebrity chairperson of The Genomics Science Black Tie Ball is Congress Women Shelia Jackson Lee. “As a Biotech Engineering company, Hybrid Medical is honored to support The Genomics Science Black Tie Ball ,” says Robert Graham, Executive Vice President of GenNXeix Biotech North America. “It is only through the medical community and philanthropic outreach that we can complete our mission, which is putting into the hands of healthcare professionals the tools they need to treat breast cancer and to improve, prolong and save patient lives.” The first and only freestanding GenNXeix Biotech Engineering center of its kind in Houston, The Genomic Biotech, is hosting the event, as well as serving as a major sponsor Lilly. “Genomics Science Black Tie Ball was put together with the same principles for why we started Hybrid Medical on the most humanistic level,” says Selene Flores., the Center’s Founder and CEO. “It is about giving back to people and the community, and bringing genomics cancer care to the next level. It is in harmony with Genomic Biotech’s philosophy, which emphasizes caring for the whole person, not just treating their disease. The most fundamental understanding of the preciousness of life is what has driven us to pursue our dream to help people with cancer–to help them live fuller lives while under our care and ideally once their disease is defeated.” Houston Press PERFORMANCES

Friday, May 11, 2012

Breast Cancer Patients A Mother’s Day Gift From The Supreme Court - Returns BRCA1 & BRCA2 Genes To Women

Robert Graham Reporting From Baylor College Of Medicine Houston, Texas May 11,2012 PressWire Hybrid Medical Media:

Breast Cancer Patients A Mother’s Day Gift From The Supreme Court - Returns BRCA1 & BRCA2 Genes To Women

Hybrid Medical Media reports that the Supreme Court remanded the case of The Association for Molecular Pathology, et al., v. Myriad Genetics, Inc., et al (Docket No. 11-725) to the Federal Circuit Court of Appeals. The question is should one company have all the rights

to a gene that is the core of breast cancer ? Docket No. 11-725 is the Supreme Court case that concerns the patents held on the BRCA1 and BRCA2 genes, which are both closely associated with the risk of developing breast and ovarian cancer. The genes were isolated by Myriad Genetics and the University of Utah, and Myriad manufactures the only test currently available to identify the two genes. In July 2011, the appellate court ruled 2-to-1 in favor of Myriad, stating that the genes could be patented because they did not occur in isolation in nature. This reversed a decision made by a US District Court in New York in March 2010 that stated that Myriad could not patent the genes. The Supreme Court made a decision regarding patents on molecular testing that prompted the nation’s highest judicial authority to ask the appellate court to reconsider its previous decision with regard to Myriad: The case of Mayo Collaborative Services, Mayo Medical Laboratories, et al., v. Prometheus Laboratories, Inc. (Docket No. 10-1150) concerned a blood test used to identify thiopurine metabolites

formed when the body breaks down thiopurine drugs taken by patients with gastrointestinal and nongastrointestinal autoimmune diseases to determine whether a prescribing physician should raise or lower the drug dosage. Breast Cancer Patients Can Now Benefit From Every Scientist In The World Working On A Cure @GenNXeix Biotech Our Science NoteBook is BRCA1 BRCA2 Compliant Gennxeix Biotech is clear to sale it's Science NoteBook to Breast Cancer Doctors. Now that the Supreme court has ruled on Myriad Genetics Inc case. The is patent protection, Patent protection is important for companies that are focusing on personalized medicine, including Gennxeix Myriad Genetics Inc. (MYGN) and Novartis AG. (NOVN) The field involves determining whether a patient is genetically susceptible to a particular disease or would be especially responsive to certain medicine. On 26 March, the US Supreme Court handed down a short summary disposition as the latest instalment in a long-running case that questions whether human genes can be patented. The Court simply vacated the 2011 decision by the Court of Appeals for the Federal Circuit (CAFC), which upheld Myriad Genetics Inc's (Myriad) patents relating to the BRCA genes, and sent the case back down to the CAFC for rehearing in light of a Supreme Court case on patenting laws of nature, handed down just six days earlier (Mayo Collaborative Services v Prometheus Laboratories, 10-1150) (Mayo). The History of. Case 10-1150 In 2009, the Association for Molecular Pathology together with many others filed suit against Myriad, the US Patent Office, and others, seeking to overturn 15 claims in seven of Myriad’s patents. The patents at issue relate to both process claims (method for detecting increased risk of breast cancer) and composition-of-matter claims (the BRCA1 and BRCA2 isolated genes). In 2010, Judge Sweet in the US District Court (SDNY) held that both the genes and methods were not patentable. In relation to the genes, they were not ‘markedly different’ to naturally occurring genes. Myriad’s argument that the technique of purifying the genes rendered the compounds patent-eligible was rejected. Judge Sweet noted the dual nature of genes as both compositions of matter and carriers of information. The fact that, even after the purification process, the information provided by the genes remained the same meant that they were unpatentable products of nature. As for the method claims, Judge Sweet relied on a ‘machine or transfer’ (MOT) test developed in an earlier CAFC decision (Bilski v Kappos) to conclude that the claims to the process of analysis or comparison in the technique were no more than ‘abstract mental processes’. However, the Supreme Court later qualified the CAFC opinion, leaving this aspect of Judge Sweet’s opinion particularly vulnerable to appeal. Unsurprisingly Myriad appealed, and last year the CAFC overturned parts of the first instance decision, finding that because isolated DNA had been ‘cleaved’ (covalent bonds in its backbone chemically severed) it was rendered a different molecule, just a fraction of a native DNA molecule, and thus patentable. However, on the method claims the CAFC largely upheld the prior decision, invalidating all claims except one on the basis that they were merely abstract mental processes. The surviving method claim was directed to a method for screening potential cancer therapies. This claim included a transformative step, satisfying the MOT test. How much guidance the Mayo case can provide for the CAFC, given that it deals with process patenting, rather than compositions of matter. In Mayo, the Supreme Court found that a process for determining dosages for a person with auto-immune disease was unpatentable. The relationship between certain concentrations of metabolites in a patient’s blood and the likelihood of under or over-dosing were merely laws of nature. Accordingly, the claimed processes were unpatentable unless they contained steps that genuinely applied the laws of nature, rather than merely constituting an attempt to monopolise the natural correlation itself. The additional steps in the claims did not transform an unpatentable law of nature into a patent-eligible application. Myriad will now have to wait for the CAFC to consider and apply the ramifications of Mayo, and decide on the composition of matter issue – probably late 2012 or 2013. For this reason, some analysists are predicting the CAFC may well uphold Myriad’s composition claims. In any event, Myriad has a suite of other patents protecting its BRACAnalysis technique which would likely deter others from its use, at least in the short term. So Myriad remains bullish on the issue, stating that it will ‘vigorously defend’ its claims because of their ‘great importance to the medical, pharmaceutical, biotechnology and other commercial industries’. Life Science Companies are free to find A Cure for Breast Cancer using Genomics.