Saturday, January 24, 2015

President Obama Community College Concept Can Work By Offering A Genomics And Bioinformatic Technology Major

Barron’s Medical Journal And B. Bobby Graham ---Reporting From Washington, DC USA ---At The Phacilitate's Washington 11th Annual Cell & Gene Therapy Forum Stem Cells as Discovery and Research Tools Forum

President Obama Community College Concept Can Work By Offering A Genomics and Bioinformatic Technology Major:


Washington DC ( AP) ----- President Obama is on to something Congress Women Shelia Jackson Lee, Congressman Al Green, Texas Governor Gregg Abbott, Houston Mayor Annise Parker and Houston Community College System. If HCC located in Houston Texas will offered a Genomics and Bioinformatic technical major, this innovative idea will create several thousand jobs and the Free Community College program will pay for itself. President Obama Community College Free For Millions Of Students. On January 9, Obama announced a plan to make community college free for "all students if they attend classes at least half time and maintain a grade point average of 2.5 or better,"

Genomics is a discipline in genetics that applies recombinant DNA, DNA sequencing methods, and bioinformatics to sequence, assemble, and analyze the function and structure of genomes (the complete set of DNA within a single cell of an organism).

President Obama Community College Concept Can Work By Offering A Genomics and Bioinformatic Technical Major Bioinformatic is the science of computer information systems. As an academic field it involves the practice of information processing, and the engineering of information systems.

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Barron's Medical Journal Interview London England's Angel Biotechnology

The Genomics and Bioinformatic course should cover gene privacy administration; Gene data disseminate, management, and interpret of large, multi-scale cloud data.

Lets discuss the need for privacy, Female patients with breast cancer (n=100) completed a questionnaire assessing attitudes regarding concerns about privacy of genomic data.

Laboratory: Sunnyvale Center: Palo Alto Scientist Interview On Genomic & Infomatics

Results Most patients (83%) indicated that genomic data should be protected. However, only 13% had significant concerns regarding privacy of such data. Patients expressed more concern about insurance discrimination than employment discrimination (43% vs 28%, p<0.001). They expressed less concern about research institutions protecting the security of their molecular data than government agencies or drug companies (20% vs 38% vs 44%; p<0.001). Most did not express concern regarding the association of their genomic data with their name and personal identity (49% concerned), billing and insurance information (44% concerned), or clinical data (27% concerned). Significantly fewer patients were concerned about the association with clinical data than other data types (p<0.001). In the absence of direct benefit, patients were more willing to consent to sharing of deidentified than identified data with researchers not involved in their care (76% vs 60%; p<0.001). Most (85%) patients were willing to consent to DNA banking. Discussion While patients are opposed to indiscriminate release of genomic data, privacy does not appear to be their primary concern. Furthermore, we did not find any specific predictors of privacy concerns.

Conclusions Patients generally expressed low levels of concern regarding privacy of genomic data, and many expressed willingness to consent to sharing their genomic data with researchers.

Cancer therapy is increasingly personalized to the molecular characteristics of a particular patient and his/her tumor.1 The National Cancer Institute (NCI) defines personalized cancer therapy as the ‘application of genomic and molecular data to tailor medical care to individuals’.

2 Personalized cancer therapy has the potential to improve treatment response, reduce adverse effects, and reduce cost of care.3 In this paper, we refer to personalized, precision and genomically informed cancer therapy interchangeably. Similarly, although the terms ‘genetic’ and ‘genomic’ have distinct scientific meanings,3a we favored the more familiar ‘genetic’ in the questionnaire administered to patients and were not strict about the distinction.

Although patients and providers express an interest in genomically informed therapy,4 concerns regarding the privacy of genomic data have been raised, particularly in the context of research.5 6 Genomic data cannot be completely ‘deidenti- fied’, 7 8 thus these data pose a serious privacy risk. As a result, the storage and sharing of genomic data in the context of research is presently a topic of much debate.9

Data from a Gallup poll10 showed that medical privacy is important to people in the general population, and privacy concerns related to genetic testing and hereditary cancers have been raised.11 However, previous studies have asked general questions about medical privacy, such as ‘Who do you think should be allowed to see your medical records without your permission?’. 10 Such questions are not representative of current research being considered or conducted where identified data are collected for specific, explicitly defined purposes. Furthermore, many studies have focused almost exclusively on healthy participants, who did not have an established relationship with a research organization where they were receiving care. Thus, previous studies may not have considered the specific privacy concerns of patients with cancer, for whom molecular testing and genetic research may have direct and indirect benefits.

Finally, little is known about patients’ privacy concerns related to molecular testing in personalized cancer therapy, which mainly focuses on information related to somatic (as opposed to germline) mutations.12 In contrast with germline mutations, somatic mutations are not heritable. Thus, from a privacy perspective, they may be less concerning to patients.

Understanding patients’ privacy concerns regarding genomic data may help researchers and clinicians better address patient concerns, and may encourage participation in genomic studies.13 Further, patients rather than the general public are the most relevant population. Our results may also help to align the public policy debate with the concerns of patients, rather than the general public.

Cloud Data and The challenges posed by the need to disseminate, manage, and interpret large, multi-scale data pervade efforts to advance understanding of cancer biology and apply that knowledge in the clinic. For several years, the volume of data routinely generated by high-throughput research technologies has grown exponentially. The storage, transmission, and analysis of these data have become too costly for individual laboratories and most small to medium research organizations to support. For optimal progress to occur, access to large, valuable data collections and advanced computational capacity must be readily available to the widest possible audience.

“ On April 7, 2013, Dr. Harold Varmus and other members of the Institute's senior leadership issued a letter to NCI grantees seeking input on these and other computational challenges they encounter on an almost daily basis. Dr. Varmus stated that the NCI, as part of its ongoing investigations into next-generation computational capabilities to serve the research community, has begun exploring the possibility of creating one or more public "cancer knowledge clouds" in which data repositories would be co-located with advanced computing resources, thereby enabling researchers to bring their analytical tools and methods to the data. Reactions to this informal request for information were generally positive, with respondents focusing on six general themes: data access; computing capacity and infrastructure; data interoperability; training; usability; and governance.”

Based in part on this information, Dr. George Komatsoulis, then interim director of the Center for Biomedical Bioinformatic and Information Technology (CBIIT), which administers the National Cancer Informatics Program (NCIP), led the creation of a concept document describing a project to develop up to three cancer genomics cloud pilots for review by the cancer-research community. Dr. Komatsoulispresented the concept (time reference 05:58:00) at a joint meeting of the NCI Board of Scientific Advisors (BSA) and the National Cancer Advisory Board (NCAB) on June 24, 2013, where it received unanimous approval.

One great example of the type Bioinformatic technology is the Very Gene project. VeryGene is developed as a curated, web-accessible centralized database for the annotation of tissue-specific/enriched genes. It currently contains entries for 3960 human genes covering 128 normal tissue/cell types compiled from the expression profiling of two large microarray data sets [ref1, ref2]. It brings together much-needed information on preferred tissue/subcellular localization, functional annotation, pathway, mammalian phenotype, related diseases and targeting drug associated with any of these genes as a result of data integration from multiple sources. Information can be searched through gene, tissue and disease views and search result can be downloaded easily. We commit our best efforts to update and expand VeryGene as new and relevant information emerges

As an initiative toward systems biology, the VeryGene web server was developed to fill this gap. A significant effort has been made to integrate TSGs from two large-scale data analyses with respective information on subcellular localization, Gene Ontology, Reactome, KEGG pathway, Mouse Genome Informatics (MGI) Mammalian Phenotype, disease association, and targeting drugs. The current release carefully selected 3,960 annotated TSGs derived from 127 normal human tissues and cell types, including 5,672 gene-disease and 2,171 drug-target relationships. In addition to being a specialized source for TSGs, VeryGene can be used as a discovery tool by generating novel inferences. Some inherently useful but hidden relations among genes, diseases, drugs, and other important aspects can be inferred to form testable hypotheses.

Two interactive matrix views have been developed to provide users with intuitive, high-level summaries of expression data and from where they can easily move to levels of greater detail. The tissue-by-developmental stage matrix provides global overviews of the spatio-temporal expression patterns of genes. The tissue-by-gene matrix enables a comparison of expression patterns between genes. Both types of matrices can be expanded (and collapsed) along the tissue axis, based on the hierarchical organization of the anatomy. Rows and columns in the matrices can be selected to refine the data set. The matrices have been added as new tabs to the gene expression data summaries. These matrices can be accessed by searches using the Gene Expression Data Query and via links from the Mouse Developmental Anatomy Browser.

The Gene Expression Data Matrix is now accessible from the Access Data section of http://www.informatics.jax.org/expression.shtml It returns all of GXD's expression data in a tissue-by-developmental stage matrix. When using this matrix, users start with a high-level overview of GXD's data and then can interactively view and select expression data for the specific tissues and / or developmental stages of interest.

The standard Gene Expression Data Query now lets users define gene sets based on genomic location. One can, for example, search for disease candidate genes that have been mapped to a genomic region and are expressed in tissues affected by the disease.

Texas can be the leader Barron’s Medical Journal.

Saturday, January 10, 2015

State Of The Union For Breast Cancer

Barron’s Medial Journal and B.Bobby Graham reporting from Southern Methodist University (SMU) Southwestern's medical school in Dallas, Texas USA


State Of The Union For Breast Cancer:

Edited in Houston, Texas by Trenette Allen


Dallas ( AP ) ---- A women getting married in 2015 under the age of 40 has an 85% chance of surviving due to a breast cancer diagnosis. Genomics and Informatics is on the goal line. Barron’s Medical Journal says a cure may happen before the end of President Obama's second term.

Informatics is the science of information. As an academic field, it involves the practice of information processing, and the engineering of information systems. It studies the structure, algorithms, behavior, and interactions of natural and artificial systems which store, process, access, and communicate information.

We spoke with the Chief Information Officer of the informatics technology company Gen-Tek Inc. and what we found was a demand in the clinical trial setting and research center across the United States is at an all- time high. In fact, an Informatics engineer has a 97% chance of having a job offer before they graduate.

Breast cancer research two major developments: targeted treatments (small molecule inhibitors and monoclonal antibodies) and massive parallel sequencing of tumor genomes, also known as next-generation sequencing (NGS). By using these platforms, a great deal of information can be obtained in a very short time.

Cancer cells are dependent on oncogenic expression to maintain malignancy, and these can be used as predictive biomarkers. Examples include the following: oncogene addiction as in HER2 amplification in breast cancer, the KIT mutation in gastrointestinal stromal tumors, epidermal growth factor receptor mutations and/or amplification in nonsmall cell lung cancer, and the BRAF V600E mutation in melanoma. Data obtained from sequencing tumors from patients with breast cancer has revealed a high level of intertumor and intratumor heterogeneity, with very few highly recurrent mutations. It has also become apparent that not every tumor has an identifiable driver mutation, and not all drivers of metastatic disease or resistance have been identified. “It is only by harnessing the knowledge from intra- and intertumor heterogeneity that we will be able to realize the application of precision medicine.

The truth of the matter is, we treat cancer today, we guess. We take what we call the average results, put it in, and see if it works. If it doesn't work, oops, we'll try another drug. If it does work, we stop the drug. When you look back 10 years from now, it's almost barbaric.

Dr. Soon-Shiong 62-year-old native of South Africa can afford to be outspoken because of his immense wealth. He doesn't need to rely on the government or Big Pharma for funding. Soon-Shiong is certain that what he terms "the Dark Age of cancer treatment" is nearly over, and "the Enlightened Age" is about to begin.

The treatment doesn't need to be painful. Metastasis doesn't need to be a death sentence. Cancer could be a chronic disease...and treated towards the cure.

While the oncology world may cringe when he boasts, as he's prone to do, patients see him differently. He believes chemotherapy works best when administered in frequent, low doses and that in some cancers the traditional method of blasting a tumor with heavy doses of chemotherapy may actually be counterproductive - because it could induce cancer cells to escape the hostile environment, enter the bloodstream and find a new home. Soon-Shiong has teamed with Blackberry to produce a device that will identify for patients and doctors what they need to make more informed decisions.

Genomics is a discipline in genetics that applies recombinant DNA, DNA sequencing methods, and bioinformatics to sequence, assemble, and analyze the function and structure of genomes (the complete set of DNA within a single cell of an organism). We then ask Rose is her company doing any work with Genomics for breast cancer and if so explain the process. Genomics is the Gaussian processes in action, to predict the likelihood of chemotherapy benefit as well as recurrence, for patients with node-negative breast cancer that is estrogen-receptor positive and/or progesterone-receptor positive. Additionally, physicians use Sam Houston to make treatment recommendations for certain node-positive breast cancer patients, and the test report also provides quantitative scores for select individual genes. Sam Houston has been extensively evaluated in thirteen clinical studies involving more than 4,000 breast cancer patients worldwide, including a large validation study published in The New England Journal of Medicine and a chemotherapy benefit study published in the Journal of Clinical Oncology. Both Medicare and private health plans covering over 90 percent of U.S. insured lives provided reimbursement for Sam Houston for patients with node-negative breast cancer that is estrogen-receptor positive and/or progesterone-receptor positive through contracts, agreements or policy decisions. Breast cancer researchers and scientists are ahead of the curve with several new technologies based on nanoparticles and semi conductors namely genomics and treatments. The field of genomics is caught in a data deluge. Targeted breast cancer DNA sequencing is becoming faster and cheaper at a pace far outstripping Moore’s law, which describes the rate at which computing gets faster and cheaper.

The result is that the ability to determine targeted breast cancer DNA sequences is starting to outrun the ability of researchers to store, transmit and especially to analyze the data. The cost of sequencing a human genome — all three billion bases of DNA in a set of human chromosomes — plunged to $10,000.00 which means genomics breast cancer DNA sequencing is around $3,000.00. The lower cost, along with increasing speed, has led to a huge increase in how much breast cancer sequencing data is being produced.

Numerous investigations have shown that both tissue and cell distribution profiles of anti-cancer drugs can be controlled by their entrapment in submicronic colloidal systems (nanoparticles). The rationale behind this approach is to increase antitumor efficacy, while reducing systemic side-effects. This review provides an update of tumor targeting with conventional or long-circulating nanoparticles. The invivo fate of these systems, after intravascular or tumoral administration, is discussed, as well as the mechanism involved in tumor regression. Nanoparticles are also a benefit for the selective delivery of oligonucleotides to tumor cells. Moreover, certain types of nanoparticles showed some interesting capacity to reverse MDR resistance, which is a major problem in chemotherapy. The first experiments, aiming to decorate nanoparticles with molecular ligand for active targeting of cancerous cells.

Miniaturization will allow the tools for many different tests to be situated together on the same small device. Hybrid Sam Houston researchers say that nanotechnology will allow them to run many diagnostic tests simultaneously. Nanoparticles nanoshells is use to antibodies that recognize cancer cells. Sam Houston scientists envision letting these nanoshells seek out their cancerous targets, then apply near-infrared light. The heat generated by the light-absorbing nanoshells can successfully kill breast cancer tumor cells while leaving neighboring cells intact.

Thursday, December 4, 2014

Neuroplasticity Can Improve Quality Of Life For Seniors

Barron’s Medical Journal Reporting from Texas Medical Center M.D. Anderson Research Center Houston, Texas USA B. Bobby Graham Reporting

Neuroplasticity Can Improve Quality Of Life For Seniors


Houston ( AP ) Neuroplasticity explains why people who knew me as a elementary student and my ability to learn is so much different as in today, where in many circles when people meet me it is clear to them they are speaking to one of superior abilities.

Neuroplasticity demonstrate that the adult brain can continue to form novel neural connections and grow new neurons in response to learning or training even into old age. Brought To You By Dream So Big Book

Neuroplasticity, also known as brain plasticity, is an umbrella term that encompasses both synaptic plasticity and non-synaptic plasticity—it refers to changes in neural pathways and synapses due to changes in behavior, environment, neural processes, thinking, emotions, as well as changes resulting from bodily injury.

The human brain is a complex, self-organizing, biological system, consisting of trillions of interconnected nerve cells called neurons. The operation of neurons results in two distinct forms of information processing: signaling and integration. Each neuron propagates signals Brought To You By JulieBeth HandBags via action potentials, electrochemical currents that travel the length of its axon. This current leads to the release of neurotransmitters which traverse synapses, the gaps between neurons. These chemical messages are received via specialized receptor cells at the ends of numerous, tree-like branches of the receiving neuron, called dendrites. The stimulation of dendritic receptors by neurotransmitters leads to integration, whereby large amounts of information from many neurons is summed up before reaching a threshold to fire the action potential JulieBeth HandBags down the next axon. In this manner, perceptual information from the external environment and the internal milieu of the body is transmitted and processed in the brain, leading to cognition, emotion, and behavior, the essence of human experience.

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The notion that social experience can lead to changes in gene expression was voiced most prominently by Nobel laureate, Eric Kandel, who regarded this observation as the core component of a new paradigm for psychiatry (1998). Kandel summarized the current state of biological thinking with regard to the relation between social experiences and neurobiology, observing that:

The regulation of gene expression by social factors makes all bodily functions, including all functions of the brain, susceptible to social influences. These social influences will be biologically incorporated in the altered expressions of specific genes in specific nerve cells of specific regions of the brain. These socially influenced alterations are transmitted culturally

The brains of infants and children are known to be plastic, undergoing spurts of neuronal development in response to stimulus exposure during critical periods. This development consists of the genesis of neurons, increased connectivity between extant neurons, and the routing of new synaptic connections between previously unrelated neurons. For instance, violinists evidence neural growth in the portion of their somatosensory cortex devoted to their fingering hand through hours of musical practice.

Persons suffering from what was once thought to be permanent brain injury can heal through rehabilitation designed to stimulate the damaged area, such as in the case of stroke However, although largely speculative, it is possible that neuroplasticity may undergird not only rehabilitation of physical illness but that of select psychological disorders as well, mediating natural recovery from mental illness in some cases as well as improvements related to psychosocial interventions. At present, it has been demonstrated that psychotherapy can induce functional changes in brain activation.

The DNA code of the human genome does not determine protein synthesis in a one-toone fashion; instead, genes are subject to epigenetic processes (i.e. modifications that do not occur due to changes in the basic genetic sequence of amino acids but that instead result from biological and environmental influences on the expression of genes as proteins During gene expression, the genetic code serves as a “blueprint” that guides the construction of proteins from amino acids. However, this construction process is modulated by signals from the internal and external environments, which steer and modify the manner in which basic organic molecules are organized into anatomy and physiology. 1. In neuroscience, synaptic plasticity is the ability of synapses to strengthen or weaken over time, in response to increases or decreases in their activity. Plastic change also results from the alteration of the number of neurotransmitter receptors located on asynapse.

Nerve cells communicate by using chemical messengers, which are released from neurons after a “priming” step. It seems that priming may be the key to controlling the strength of chemical transmission. The roots of cognition, behavior, learning and memory are embedded in the brain’s intricate network of nerve cells and their specialized points of contact, the synapses. Synapses can convert electrical impulses into chemical signals and back again, as well as modulate the strength of the transmitted signals. This ability to modify the strength of transmission—known as synaptic plasticity—is thought to be the cellular basis of the brains ability to compute, learn and remember. A goal of many neurobiologists is to understand the molecular basis of synaptic plasticity

Neuroinformatics stands at the intersection of neuroscience and information science. Other fields, like genomics, have demonstrated the effectiveness of freely-distributed databases and the application of theoretical and computational models for solving complex problems. In Neuroinformatics, such facilities allow researchers to more easily quantitatively confirm their working theories by computational modeling. Additionally, neuroinformatics fosters collaborative research—an important fact that facilitates the field's interest in studying the multi-level complexity of the brain.

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There are three main directions where neuroinformatics has to be applied:[2] 1. the development of tools and databases for management and sharing of neuroscience data at all levels of analysis,

2. the development of tools for analyzing and modeling neuroscience data,

3. the development of computational models of the nervous system and neural processes.

Saturday, November 22, 2014

Fashion Week Houston Makes Downtown Feel like New York City Without The Stress

Fashion Week Houston makes Downtown feel like New York City without the stress

Barron's Medical Journal Style Reporting from Houston Fashion Week Houston, TX USA -- Contributing Editor: Trenette Allen

Bobby Graham Reporting From Downtown Houston --- Houston, Texas USA GlobeNewswire>< PRWire> < PRNewswire>

Houston --- ( AP ) In one of the greatest weeks in my life where my son had his first child, who is now living in Virginia, and my daughter received a major award at her work place and is relocating to Atlanta GA , -- I said to myself the Houston, TX they were born in, is not the Houston of today. If you take this week alone, Mayor Parker is bring businesses back in to downtown Houston. No better example of this greatness is the Houston Fashion week shows put on every year by Jared Lang and Audi of North America. This year’s show was anchored by one of the fashion geniuses of the designer world, Mr. David Peck. David is ready for the global fashion world. Neiman Marcus, Saks Fifth Ave you need to find space for David Peck’s designs. Models ignited the sold -out crowd to standing ovations.

The Marriot Corporation opened one of its grandiose locations to date. The Downtown Houston JW Marriot Opening Party showed off again their new uniform collection for hotel associates (aka employees).The seriously stylish collection was actually inspired by the 104-year-old Samuel F. Carter Building, which was Houston's first skyscraper and which now houses the luxury hotel brand. A custom blouse print even features a photograph of the building taken in 1910.

David Peck USA designed the men's and women's line which features classic silhouettes for the ladies in the form of pencil skirts, structured jackets, sheath dresses and blouses with neckties and chiffon panels and for the men, neutral tones with splashes of bright blue and peridot and some dandy accessories like bow ties and suspenders. Both the women's and mens lines feature custom, hand-woven and fair trade tweed in several pieces.

Also opening in its new location, was the Esperson Gallery in the Houston Pavilion . While there Barron’s Medical Journal found the Christmas find of the year. My heart just dropped when JulieBeth showed her handbag line. Yes, Mayor Parker Downtown Houston has a super star. Beth Younger Purpich is the CEO and designer. Beth uses her Auburn University degree and MBA from the Weatherhead School of Management (Case Western Reserve University) on a daily basis. She loves using both the left and right side of her brain to design and also manage. Beth's love of leather goods can most likely be attributed to her time spent on her family's century-old cattle ranch in Middle Tennessee. Beth has spent most of her life as a basketball player (Auburn University) and even did a year stint in Australia upon graduation, where she was paid to play...in beer. True story. Just don't ask her about the uniforms...yikes! See For Yourself The Ideal Bag For Christmas says Fashion Writer B.Bobby Graham

Judith team includes Phillip Purpich who is the Chief Operating Officer and manages the operations and supply chain for JulieBeth. Phillip has a degree in Chemical Engineering from Texas A&M University. Phil serves on the board of directors of the Education Foundation of Harris County and lives with his wife, Beth, in Houston, Texas. JulieBeth prides herself on superior quality and most importantly, superior customer service. “We are in business because we love making our customers supremely happy! Should you choose to make a return, you may do so up to 14 days from the delivery of your bags. “

All bags are hand-cut and stitched by artisans using top-grain leather and superior hardware. JulieBeth selects only the best and believes streamlined designs with clean lines make the best accessories. All JulieBeth Handbags interiors come with luxurious cerise lining, sturdy metal zippers and detailed leather trim. The creative process begins with a design idea and finishes with a handcrafted luxury bag. Ideas come from anywhere. In fact, the Cocktail Napkin was designed at a speakeasy in Kansas City by simply folding a paper napkin onto itself. JulieBeth believes the best designs are simple and functional and all bags are handmade to order, one at a time. Yes , Houston is looking and feeling like Manhattan in New York City USA. Again, Houston Fashion Week starts the Christmas season with style and awe.


Thursday, November 13, 2014

How Did That Lump Get On Your Breast

Barron's Medical Journal Reporting From John Hopkins University Baltimore Md USA

Governors of Texas Greg Abbott And Maryland‘s Larry Hogan Mandate: How Did That Lump Get On Your Breast

Houston ( AP ) --- Barron’s Medical Journal ask the question: How did that lump get on to your breast. B.Bobby Graham Interviewed Rose Conrad Ph.D. Conrad responded with a smile on her face and said let’s open up the breast cancer playbook. Two Companies are leading the way in the personalized medicine space. Genomic Health and Base Health has mastered the science says Barron’s Medical Journal. What is needed is for the newly elected Governors of Texas Greg Abbott And Maryland‘s Larry Hogan to collaborate using Rice University Rice University Institute of Biosciences and Bioengineering and Texas A&M Health Science Center Institute of Biosciences & Technology in Houston. The FDA and a World of Biotech Companies plus National Institute of Health is located in Maryland. Universities like John Hopkins collaborating together can put a end to breast cancer.

Genomic Health, Inc. (NASDAQ: GHDX) is a global cancer company focused on the development and commercialization of genomic-based clinical laboratory services that analyze the underlying biology of cancer allowing physicians and patients to make individualized treatment decisions.

Over the past decade, we have redefined personalized medicine through the innovation of Oncotype DX, making genomics an indispensable part of breast, colon and prostate cancer diagnosis and treatment. BaseHealth™ makes an integrated health management platform that combines genomic data with clinical and behavioral analysis to engage patients with their physicians in a highly-collaborative way. Our evidence-based assessments help physicians intervene early and often with tailored action plans that span each patient’s unique activity, diet, environmental and lifestyle needs. Personalized medicine starts with a comprehensive understanding of the individual, around whom today’s most successful physicians orient care. This is the first time that a patient can responsibly explore genomic data and non-genomic data in one place, in collaboration with their physician.

Oncogene are genes that take your genes and DNA and convert the your genes to breast cancer genes. The most known gene associated with breast cancer is the KCNK9 Gene. KCNK9 encodes a potassium channel that allows the breast cancer tumor to grow on your breast. This process is aided by Hypoxia. Hypoxia refers to an inadequate oxygen supply to the cells and tissues of the Breast. The Main Gene that stops the growth of KCNK9 Genes is gene is p53. p53 is a fundamental determinant of cancer susceptibility, p53 integrates stress signals and elicits apoplectic responses that maintain genomic stability.

In 2006 and 2007, promising to take customers’ DNA and create personalized health reports to help us understand the medical risks lurking in our genomes, the pressures facing genomic health services seemed clear. Sequencing a human genome was prohibitively expensive, coming in at well over a million dollars — would they be able to narrow down their DNA targets enough to come in at an attractive price point, while still collecting useful information? Would the FDA and other regulators smile on these products, or regard them as unproven medical tests? Was there even a market for DNA data?

Fast forward to today, and the whole business of genomic health looks very different indeed. The genome is a commodity within reach of the middle class, coming in at the price of a cheap used car. Genetic health reports are decidedly “medical devices,” and the FDA is vocally worried that consumers could be dangerously misinformed if providers don’t go through a careful regulatory process.

When cells sense a decrease in oxygen availability (hypoxia), they develop adaptive responses in order to sustain this condition and survive. If hypoxia lasts too long or is too severe, the cells eventually die. Hypoxia is also known to modulate the p53 pathway, in a manner dependent or not of HIF-1 (hypoxia-inducible factor-1), the main transcription factor activated by hypoxia. The p53 protein is a transcription factor, which is rapidly stabilized by cellular stresses and which has a major role in the cell responses to these stresses. This process is why it is important Conrad says for people that are first degree relatives of breast cancer patients, must take a genomic test to see if they are the carrier of gene KCNK9. By identifying this gene we can direct patients with the correct advise as to deal with the fact that they have a lunp on the breast to they are going to get a lump on their breast. Often what happens is that a breast cancer patients dose not go to the doctor or take important test to see if there is a lump on the breast. what happens is the spread of breast cancer is responsible for more than 90 percent of breast cancer deaths. The process by which breast cancer spreads — or metastasizes is where Metastasis was long thought as a late event in breast cancer progression, With Genomics we now shown metastasis to be an early event that is dependent on Hypoxia HIF-1. HIF-1 protein controls genes that enable cells to survive in low oxygen, like cells in solid breast tumors. In order for breast cancer cells to spread to lungs, they must leave the breast,enter blood vessels that lead to the lungs, and exit those same vessels. “

Blood vessels are pretty tight; a cell has to work pretty hard to get through the vessel wall. How this process works is breast cancer cells turn on genes called ANGPTL4, ANGPTL4, helps breast cancer to travel through blood vessel walls. Research is now being performed with Genomics. The Gennxeix Biotech Team found by injecting these cells either with normal or “knocked-down” levels of ANGPTL4 into mice and examining their lungs. Cells lacking HIF-1 and containing extra ANGPTL4 were better able to invade the lungs than cells without extra ANGPTL4. There are other genes that are involved in the creation of a breast cancer tumor on the breast. Her-2, p63, 73. Conrad goes on to say that in their genomic test uses 21 different genes to project ,stop the growth and the spread of a patients breast cancer Lump. HIF-1 as a therapeutic target can extend the life of many stage four breast Cancer patients.
Gennxeix discovered The tumor suppressors VHL (von Hippel-Lindau protein) and p53 target HIF-1α for ubiquitination to inactivation breast cancer tumors cells increases the of HIF-1. This process Increased phosphatidylinositol 3-kinase (PI3K) and AKT.

In breast cancer, increased activity of the HER2 (also known as neu) receptor tyrosine kinase is associated with increased tumor grade, chemotherapy resistance, and decreased patient survival. HER2 has also been implicated as an inducer of VEGF expression. GenNXeix demonstrate that HER2 signaling induced by over expression in mouse 3T3 cells or human MCF-7 breast cancer cells results in increased HIF-1α protein and VEGF mRNA expression that is dependent upon activity of PI3K, AKT (also known as protein kinase B), and the downstream kinase FRAP (KBPS-rapamycin-associated protein)
Gennxeix concern with patients with diabetes and breast cancer may not receive full Benefit of HIF-1. All women having access to a physician can have access to HIF-1 treatments