What is Better Than a Mammogram and can Help The Obama Administration Create 4 Million Jobs

What is Better Than a Mammogram and can Help The Obama Administration Create 4 Million Jobs
Robert Graham and Hybrid Medical Media Reporting from Rice University September 6, 2011

What is Genomics? Genomics is a new and fast expanding area of biology encompassing high throughput or large scale experimentation at the whole genome level, and the organization, analysis and interpretation of the huge amount of data emerging from genome projects. Major new technologies have evolved recently that enable experimentation at the whole genome level, and more novel technologies are currently being developed. This volume describes in detail the new technology necessary to study the entire genome in a holistic manner and all the high throughput and large-scale experimental methodologies currently being used in genomic science. In addition the authors describe the progress of the newest technologies that are currently being developed. Written by experts in the field, this concise yet informative volume covers all aspects of technology pertaining to genomic studies. It is an essential book for anyone involved in genomic science.


Breast Cancer patients can aligning environmental science with regulation, Genomics in Regulatory Ecotoxicology: Applications and Challenges presents the first in-depth set of recommendations published in the open literature focused specifically on how genomics data could be used in regulatory ecotoxicology. The book develops a conceptual framework of how genomics data can most effectively impact current approaches for ecological risk assessments. It also identifies biomarkers of exposure and effects for both lab and field monitoring studies and provides a basis for the extrapolation of chemical effects across species. It explores exactly how data generated from new genomics technologies might impact or benefit risk assessment. Features: Identifies biomarkers of exposure and effects for use in both lab and field studies, Provides a basis for the extrapolation of chemical effects across species, Describes current and planned applications of genomic technologies to screening assays for use in ecotoxicology decision-making, including risk assessment, Focuses on the development and application of genomics to tiered testing, including how genomics may be used to support streamlining of current chemical testing programs, Highlights the application of genomic technologies to complex mixtures of contaminants in the environment, such as sites requiring remediation.
Breast Cancer Genomics in Regulatory Ecotoxicology: Applications and Challenges is one of many SETAC publications that offer timely, innovative, and critically reviewed perspectives on current topics relating to broad environmental toxicology and chemistry issues. SETAC assumes an active leadership in the development of educational programs and publishes the peer-reviewed, international journals Environmental Toxicology and Chemistry and Integrated Environmental Assessment and Management.

GenC has new technology to systematically quantify proteins within a small sample by coupling antibody-mediated protein binding with qPCR quantification. The assay probes are target-specific antibodies that are conjugated to two different oligonucleotides through a biotin-streptavidin linkage. When the antibodies bind their target, the oligos come in proximity of each other. Addition of a connector oligonucleotide and DNA ligase creates a DNA amplicon, which is amplified in a qPCR reaction. The qPCR results correlate with the amount of protein in a sample.

Often these are analyzed using immunohistochemistry, but that is much more labor intensive and much less quantitative. Thus, studies now can be conducted with greater ease and throughput with actual tumors. This will allow a better understanding of the protein profiles of cancers, and thus potentially identify new therapeutic biomarkers.

A nanometer is a billionth of a meter. It's difficult to imagine anything so small, but think of something only 1/80,000 the width of a human hair. Ten hydrogen atoms could be laid side-by-side in a single nanometer.

GenConnect minuscule molecule that will be used to detect breast cancer is a quantum dot. Quantum dots are tiny crystals that glow when they are stimulated by ultraviolet light. The wavelength, or color, of the light depends on the size of the crystal. Latex beads filled with these crystals can be designed to bind to specific DNA sequences.

Hybrid GenConnect will Reduce Breast Cancer by 5 percentage points by 2014