NFL Players Using Violence Against Themselves – Is Gene TDP-43 In Adults And Gene MYCN or CD44 In Kids The Reason

Barron’s Medical Journal Reporting From The Home Of The Texans Reliant Park In Houston Texas

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National Football League

Players Using violence Against Themselves – Is Gene TDP-43 In Adults And Gene MYCN or CD44 In Kids The Reason Why:

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Folks are looking for answers to why too many National Football League players are using violence against themselves. Barrons Medical Journal ask Gennxeix Biotech CEO

for answers. To our surprise Rose Conrad Gennxeix CEO says that it has been known for years that some football players have a gene called TDP- 43. TAR DNA-binding protein of 43kDa (TDP-43). Genomics is again the key to equalize a patient’s risk. Conrads says new Genomics genetic risk factor for amyotrophic lateral sclerosis, commonly known as ALS or Lou Gehrig's disease

There is no cure for ALS and the current treatment only slows disease progression. The identification of pathological interactions between ataxin 2 and TDP-43, another ALS-associated disease protein, together with the strong genetic association of ataxin 2 intermediate-length polyQ expansions and ALS, should aid in the development of biomarkers and empower the development of new therapies for this disease.

Parents can look for in their kids called Neuroblastoma. 8% of 30 Million Uninsured has Familial Cancer 1% of the 8% Kids has the ALK Gene on Chromosome2 that results in Neuroblastoma Cancer. Gennxeix Biotech Analytics Business Intelligence CIO Reports - 50% of the Moms with the Gene MYCN or CD44 Kids will have Neuroblastoma Cancer. The way Moms can recognized Neuroblastoma is a Abdominal Mass. The symptoms in high-risk patients are due to this tumor mass or bone pain from the cancer metastases. Extensive bone marrow metastasis may result in pancytopenia. Abdominal distention with respiratory compromise due to massive liver metastases may occur in infants. Because they originate in paraspinal ganglia, neuroblastomas may invade through neural foramina and compress the spinal cord extradurally, causing paralysis. The survival rate is twice as high if diagnosed in infants less that one years old. Genes that encode RNA-binding proteins (RBPs) such as PTB, hnRNP L, and SRSF1 are autoregulated to maintain a constant level of mRNA (Buratti and Baralle 2011). This autoregulatory process may be achieved in part by selective alternative splicing events that trigger nonsense-mediated decay (NMD)-mediated RNA degradation (Lejeune and Maquat 2005). The general term RUST (regulated unproductive splicing and translation) has been proposed to describe this category of gene regulation (Lareau et al. 2007a). Conrad also says that science labs use Genomics to generated multiple antibodies specific to phosphorylated TDP-43 by immunizing phosphopeptides of TDP-43, and analyzed

FTLD-U and ALS brains by immunohistochemistry, immunoelectron microscopy, and immunoblots. In addition, we performed investigations aimed at identifying the responsible kinases, and we assessed the effects of phosphorylation on TDP-43 oligomerization and fibrillization.

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Barron's Medical Journal has called for a meeting between President Obama, Governor Rick Perry and President of MD Anderson Ronald DePinho, M.D. Medical Teams. The Objective is to put together a road map that will allow new born babies born Today to live 22 percent longer. President Obama Health Care Reform Act, Rick Perry commitment to Stem Cell Research, And Ronald DePinho & Jim Allison Chief of Immunology at MD Anderson vision and proven 24% success rate with immune research. Together it is clear, Genomic Science is here to stay.