Walked A Mile For Breast Cancer A BMJ -- " Status Report: "

Barron's Medical Journal Reporting From The University Of Texas -- Austin, Tx USA

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Walked A Mile For Breast Cancer A BMJ -- " Status Report: "

A Breast Cancer Cure Before the end of President Obama 2nd Term And By The End of 115th Congress.

Of course the advent of Genomic Science and CPRIT makes this possibility-- Possible. To move this lofty goal forward we must get the republican lead 114th Congress to send over to the president desk H.R 2191. More on CPRIT later in this Article.

You may by now be saying what is H.R. 2191? --- H.R.2191 purpose is "To amend title 39, United States Code, to extend the authority of the United States Postal Service to issue a semipostal to raise funds for breast cancer research, and for other purposes. " As the leading Breast Cancer publication -- Barron's Medical Journal has decided to be a voice to help move this Bill through Congress.

Houston's #1 Kitchen And Bath Designers Base on our research and analysis we feel Congresswomen Karen Bass Of California 37th District , should become a Co-Sponsor and join the H.R. 2191 Sponsor Jackie Speier of California 14th District. State District In Congress California 14 House: 113th-114th (2013-Present) California 12 House: 110th-112th (2008-2013)

A Little known to many Karen , Prior to serving in Congress, Congressmember Bass made history when the California Assembly elected her to be its 67th Speaker, catapulting her to become the first African American woman in U.S. history to serve in this powerful state legislative role. Congress member Bass served as speaker during California’s greatest economic crisis since the Great Depression. In addition to helping to navigate the state through a very difficult time, she also championed efforts to improve foster care and quality healthcare for Californians. Also, under her leadership the Assembly fast-tracked federal economic stimulus legislation that aided Californians who have been affected by the national economic crisis as well as jumpstarted billions of dollars of infrastructure project

She was selected by Democratic Leader Nancy Pelosi to serve on the prestigious Steering and Policy Committee, which sets the policy direction of the Democratic Caucus, as Organization, Study and Review Chair. Congressmember Bass is also playing a leadership role in the Congressional Black Caucus (CBC), where she serves as Secretary for the 114th Congress.

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She grew up with three brothers in the Venice/Fairfax area of Los Angeles and is the only daughter of DeWitt and Wilhelmina Bass. She graduated from Hamilton High School, Cal State Dominguez Hills, and the University of Southern California’s School of Medicine Physician Assistant Program.

The 2nd fascinating Breast Cancer Opportunity to have a Cure by the end of The President 2nd Term is The Big News out of Austin, Texas CPRIT Surpasses the 2 Million Milestone in Life-Saving Cancer Prevention Services Provided to Texans

Nearly 1,500 cancers have been detected through screenings and diagnostics The Cancer Prevention and Research Institute of Texas (CPRIT) today announced that it reached a new milestone: more than 2 million cancer prevention services have been provided to Texans in all 254 counties of the state. Prevention measures made possible by CPRIT grants include tobacco cessation programs, vaccinations, screenings for breast, cervical, and colorectal cancers, genetic testing and counseling, and survivor care. “This is a momentous occasion in CPRIT’s history and it demonstrates how Texas leads the nation in the fight against cancer,” said Wayne Roberts, the agency’s chief executive officer. “Our innovative and proven cancer prevention strategies are saving or extending the lives of thousands of Texans who ordinarily might not have access to screenings and diagnostics. The greatest opportunity to reduce the burden of cancer is by reducing its incidence – preventing it altogether.”

Since 2009, CPRIT has delivered 2,211,119 prevention services to Texans. Those include 1,105,907 education and training services and more than 1.1 million clinical services, which have resulted in: 16,562 prevention vaccinations; 189,842 Texans receiving tobacco cessation services; 17,036 Texans receiving genetic testing and counseling, and 10,743 Texans receiving survivor care

“I get asked, ‘When are we going to find a cure for cancer?’” said Dr. Becky Garcia, CPRIT’s chief prevention and communications officer. “My response is that we have a cure for cancer. It’s prevention. For example, if people stopped smoking, an estimated 80 percent of lung cancer deaths could be prevented along with 30 percent of other tobacco related cancers.” Visiting Houston Make Sure You Visit Rothko Chapel To date, CPRIT has funded 146 cancer prevention grants totaling $142,189,920. Of the 1,105,212 clinical preventive services delivered, there have been 528,645 screenings and diagnostics for breast, cervical, colorectal, and liver cancers. Of these:

42,991 abnormal results were identified; 3,340 cancer precursors were detected, and 1,477 cancers were found. One woman in her early thirties discovered she had breast cancer after completing a CPRIT-funded screening in East Texas. “My world fell apart, but if I had not discovered the program, my tumor would have just kept growing,” she wrote. Following a mammogram, biopsy, and five surgeries, she remains cancer free. (Watch patients recount their personal battles against cancer at http://www.cprit.state.tx.us/prevention/patient-stories/.) In the Dallas area alone, the CPRIT-supported Bridge Breast Network has detected 226 cancers, including seventy-eight percent in the early stage. “That’s 176 women who have a better chance at survival now,” Dr. Garcia said. “It makes a huge difference detecting breast cancer early when treatment is most effective.” Up to ten percent of the total amount of money CPRIT awards each year is specifically devoted to delivering cancer prevention programs and services in Texas. Currently, CPRIT supports 55 prevention projects throughout the state, including: Grantee: Dr. Abbey Berenson, The University of Texas Medical Branch at Galveston Project: HPV Vaccinations Dr. Berenson’s project targets low income pregnant women to take advantage of opportunities for prevention when these women access the health care system. The program serves populations that typically have very low HPV vaccination rates by implementing standing orders for postpartum HPV vaccination(s) during regular doctors’ visits associated with pre and postpartum care. Impact: This program increased the HPV vaccination rates from 9 percent to 83 percent its very first year of operation.

Grantee: Dorothy Gibbons, The Rose (Houston) Project: Breast Cancer Screenings The Rose’s Empower Her to Care project increases mammography screenings among underserved minorities in 24 Texas counties through an expanded Mobile Mammography Outreach program. The program provides free, easily accessible breast cancer screenings in the neighborhoods where the women work and live, increasing public awareness of the importance of identifying breast cancer in its earliest stages. Impact: To date, the project has served 5,044 women; 1,800 of these women had never before been screened.

Grantee: Texas Tech University Health Sciences Center (TTUHSC) at El Paso Project: Colorectal Screenings Collaborating with more than 20 organizations, TTUHSC at El Paso has developed Project ACCION, a bilingual program that provides free education and screening services for a high-risk, underserved population. Impact: Through the program, thousands of Texans have received education and screenings. To date, 36 people have had abnormal growths detected; seven of the people were found to have cancer and steered into treatment.

Grantee: The University of Texas Southwestern Medical Center (Dallas) Project: Identifying Patients with Hereditary Breast-Ovarian Cancer and Lynch Syndrome Through the only telemedicine program of its kind in Texas, genetic counseling is provided to populations who have never received services, with the goal of identifying patients with Hereditary Breast-Ovarian Cancer (HBOC) and Lynch syndrome--two of the most commonly inherited cancer predisposition syndromes. Impact: In the first 20 months, more than 61,000 underserved women were screened for HBOC risk and more than 500 underserved patients with colon and uterine cancer were tested for Lynch syndrome. Additional funding from CPRIT will expand the reach of this project from six to 22 counties in North Texas.

Grantee: Dr. Carol Rice, Texas A&M AgriLife Extension Service (College Station) Project: Breast and Cervical Cancer Screenings in Rural, Frontier and Border Counties The program targets underserved women in 50 counties and helps them make appointments for breast and cervical cancer screenings. Impact: Screenings of 3,157 women have detected 198 abnormalities, including 42 cancer precursors. Indicating the high demand for services, the project’s outreach has impacted 7,590 women in nearly three years—more than twice the original goal. For More Information Contact Congress.gov

LOX Can Save Your Life If You Have Breast Cancer:

LOX Can Save Your Life If You Have Breast Cancer:

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Barron’s Medical Journal reporting from M.D Anderson In The Texas Medical Center Houston, Texas USA

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Houston ( AP ) --- The fight against breast cancer has taken a major step forward. Barron’s Medical Journal has discovered the monoamine oxidase lysyl oxidase LOX gene is responsible for breast cancer spreading to your bones. It is important to note – no one dies from breast cancer on your breast. Breast cancer patients die when breast cancer spreads to your bone and lungs.

This is A Special Report For President Obama And Congress to start expecting a breast cancer cure by the end of this the 2nd term.

A super fantastic finding was found by Dr. Gartland and colleagues a group of Researchers from the UK and Denmark have discovered a protein that encourages breast cancer to spread to the bone the finding that has paved the way for treatments that halt progression of the breast cancer disease

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Dr. Gartland found that when breast cancer cells are deprived of oxygen, they release high levels of LOX. This protein makes holes in the bone of breast cancer patients as a way of preparing it for the arrival of cancer cells. The main cause of mortality among cancer patients is generally secondary, or metastatic, tumours, but few selective drugs have been identified that specifically target metastasis itself. Now, an exciting report from Erler and colleagues describes the involvement of the monoamine oxidase lysyl oxidase (LOX) in several stages of the migration of malignant cancerous cells from their primary tumour formation site, establishing a new therapeutic target for preventing and treating metastases.

"We show that these lesions subsequently provide a platform for circulating tumor cells to colonize and form bone metastases,". In another part of the study, the team found that introducing LOX to tumor-free mice also led to bone damage. However, they found an existing drug called bisphosphonate - used to treat bone diseases such as osteoporosis - prevented such damage in these mice.

As such, the authors suggest that administering similar treatments to patients with breast cancer could stop the disease spreading to the bone.

Commenting on the findings, study co-leader Dr. Janine Erler, of the University of Copenhagen in Denmark, says:

"Once cancer spreads to the bone it is very difficult to treat. Our research has shed light on the way breast cancer cells prime the bone so it is ready for their arrival. If we were able to block this process and translate our work to the clinic, we could stop breast cancer in its tracks thereby extending patients' lives."

The researchers say their next step is to determine how LOX interacts with bone cells to drive cancer metastasis, which will bring us closer to finding drugs that stop the process. "This could also have implications for how we treat other bone diseases too," adds Dr. Gartland.

Earlier this month, Barron’s Medical Journal reported on a study published in the British Journal of Surgery, which suggests women with hereditary breast cancer are at no higher risk of poor treatment outcomes than breast cancer patients without a family history of the disease.

The lysyl oxidase (LOX) family is an emerging family of amine oxidases that is responsible for lysine-mediated crosslinks found in collagen and elastin. Several novel functions, such as tumor suppression, tumor progression, cellular senescence, chemotaxis and the modification of histones have recently been attributed to the LOX family of proteins. In the search for more human LOX paralogs, in the present study, we identified several expressed sequence tag (EST) clones that showed an alternative exon-intron splice pattern from LOX. These ESTs corresponded to the LOX transcript variant 2 (LOX-v2) that was recently reported in GenBank (accession no. NM_001178102). LOX-v2 mRNA lacks exon 1 of LOX, but contains an additional 222 bp sequence from the 5'-flanking intronic region of exon 2. The deduced LOX-v2 polypeptide contains the characteristic C-terminal domains of the LOX family, but does not contain the N-terminal propeptide region that has been reported to have tumor suppressor activity. In peroxidase-coupled fluorometric assays, LOX-v2 showed β-aminopropionitrile-inhibitable amine oxidase activity toward collagen and elastin. RT-PCR analysis of human tissues revealed a distinct tissue specificity of LOX-v2 expression compared to that of LOX. Promoter assays indicated that an alternative promoter element present in the exon 1 region of LOX was sufficient for the differential expression of LOX-v2. These findings indicate that the human LOX gene encodes 2 variants, LOX and LOX-v2, both of which function as amine oxidases with distinct tissue specificities.

For the science readers:

Entrez Gene summary for LOX: The protein encoded by this gene is an extracellular copper enzyme that initiates the crosslinking of collagens and elastin. The enzyme catalyzes oxidative deamination of the epsilon-amino group in certain lysine and hydroxylysine residues of collagens and lysine residues of elastin. In addition to crosslinking extracellular matrix proteins, the encoded protein may have a role in tumor suppression. Defects in this gene are a cause of autosomal recessive cutis laxa type I (CL type I). Two transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq)

The results of a very important discovery Lox Gene Targeting Results in Perinatal Lethality—A gene- targeting vector was designed to eliminate Lox expression by converting the translation initiation codon (ATG) into a trans- lationally inactive NotI restriction site and inserting the phos- phoglycerate kinase promoter driving the neomycin antibiotic resistance gene (PGK-Neo) (Fig. 1A). This construct was elec- troporated into embryonic stem cells (129/SvJ), and clones un- dergoing homologous recombination were injected into blasto- cysts. Resulting chimeric mice were bred to C57BL/6J mice yielding germ line transmission of the targeted allele. Breeding of heterozygous null LOX mice resulted in 0 of 400 animals that were homozygous for the targeted allele at 3 weeks of age. Timed matings were set up to determine the fate of LOX􏰁/􏰁 mice. LOX􏰁/􏰁 mice were observed by genotype late in gestation and at parturition with proper Mendelian inheritance (Fig. 1B). Grossly, LOX􏰁/􏰁 mice were of similar size to wild type and heterozygous littermates at late gestation and parturition.

LOX gene targeting results in decreases in both collagen and elastin cross-links in vivo, confirming the catalytic capacity of LOX demonstrated in vitro. Despite the presence of five lysyl oxidase enzymes, LOX deficiency is lethal, suggesting that other lysyl oxidases are unable to effectively compensate dur- ing development for the physiological stresses associated with parturition and life ex utero. LOXL1 mRNA does not increase to compensate for LOX deficiency in the total embryo. The inabil- ity of the other lysyl oxidases to compensate may relate to either distinct substrate specificities of individual enzymes or temporally and spatially unique expression patterns.

This why Barron’s Medical Journal senior science writer says we are going to find a cure by the end of President Obama 2nd term.

Washington DC And The Offshore Technology Conference Is Shaping Your Summer Gas Prices:

Washington DC And The Offshore Technology Conference Is Shaping Your Summer Gas Prices:

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B.Bobby Graham Reporting From The Offshore Technology Conference In Houston, Texas USA < GlobeNewswire>< PRWire> < PRNewswire>

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WASHINGTON — It started at this year’s Offshore Technology Conference. The Oil and Gas Industry looking at the United States for leadership on oil prices. President Barack Obama welcomed Saudi Arabian leaders to the White House Today amid strains with the kingdom over his pursuit of a nuclear deal with Iran.

As he opened their Oval Office meeting, Obama said the U.S. and Saudi Arabia were building their relationship "during a very challenging time." Beyond the Gulf nation's worries about Iran, Saudi Arabia and other countries are deeply concerned about the rise of the Islamic State and instability in Yemen.

This year’s Offshore Technology Meeting Made a group of engineers from Houston proud. Yes The Cameron Iron company showed the Offshore Technology Conference and the rest of the world their new Subsea Product.

Subsea is a term to refer to equipment, technology, and methods employed in marine biology, undersea geology, offshore oil and gas developments, underwater mining, and offshore wind power industries.

The Reason why Cameron Iron was able to win award was part due to their new, Subsea Services Alliance, the collaboration between Helix Energy Solutions Group, Inc. (NYSE: HLX), OneSubsea®, a Cameron (NYSE: CAM) and Schlumberger (NYSE: SLB) company, and Schlumberger, is pleased to announce the first joint technology project between OneSubsea and Helix to engineer and manufacture a 15,000-psi intervention riser system.

This jointly developed technology advances the alliance's objectives to offer well intervention solutions to service the increasing number of high-pressure wells in the subsea environment. The system, which will be available on a rental basis in mid-2017, is being engineered and built at OneSubsea facilities in Leeds, UK.

Helix President and Chief Executive Officer, Owen Kratz said, "This new jointly-owned system will allow us to service a wider range of our client's well stock. It shows that even in a downturn we are able to target new and exciting opportunities." OneSubsea Chief Executive Officer, Mike Garding stated, "By combining the operational expertise of Helix Energy Solutions with OneSubsea's world class engineering and manufacturing capability, we are creating well access and control packages that will expand today's operating envelope to deeper and higher temperature environments. The announcement for the 15,000-psi intervention riser system is one of the first steps we are taking on the road to become the pioneers in subsea well intervention."

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Subsea is a rising technology in the Global Oil and Gas Markets.The Subsea Production Market. Subsea engineering, in which wellbores are drilled through the seabed, is typically carried out for the extraction of petroleum. Escalation of demand for energy and the nearing maturity of onshore resources are driving the momentum toward subsea engineering. The White House is expected to offer the Gulf nations more military assistance, including increased joint exercises and coordination on ballistic missile systems. The package of assistance would be aimed at reassuring the region that the U.S. will guard its security against potential Iranian aggression.

Some Gulf nations wanted Obama to commit to a formal defense treaty, but U.S. officials have told leaders the president will not agree to such a measure.

The Saudi king isn't the only head of state skipping the meetings in Washington. The heads of the United Arab Emirates and Oman have had health problems.

Bahrain's King Hamad bin Isa Al Khalifa will be in Britain Thursday to attend an event at Windsor Castle and meet with Queen Elizabeth II.

An increase in oil and gas drilling activity has helped subsea oil production gain traction, with the EMEA region leading the pack. With governments worldwide, shifting their focus to offshore oil and gas reserves, their interest will dispense growth in the market, as indicate TechNavio insights.

The market has witnessed technological advancements and key market players are investing heavily toward subsea engineering and offshore oil and gas exploration. FMC Technologies, with the largest market share in production, is penetrating further by leveraging its engineering and technical expertise. FMC intends to capitalize on the growth opportunities that lie in APAC, Brazil, North Sea, and West Africa.

With the price of Oil at $61.30 you can bet your Vacation Is going to see a increase. Lets just hope inflation and interest rates will not see a increase.

Can Your Same Sex Marriage Be Validated By XQ28

Can Your Same Sex Marriage Be Validated By XQ28

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Barron’s Medical Journal ---- B.Bobby Graham Reporting : ---- From Surpreme Court Washington DC -- USA < GlobeNewswire>< PRWire> < PRNewswire>

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Same Sex Marriage -Changing Thousands Years Of Thinking In Only Ten Years :

Washington DC -- BMJPress -- The United States Supreme Court Is making a decision on Same Sex Marriage. The question is should we change thousands years of thinking after only considering about ten years of courts cases. At Barron Medical Journal we decided to look under the hood on this issue and investigate the science behind this matter. Barron’s research shows scientist have identified gene’s associated with being gay in males.

Some background on human genes and its DNA associations. A gene is a physical structure made from DNA. Genes function primarily by being expressed in the form of proteins. The conversion from gene to protein is a multistage process. First the gene is transcribed, making a RNA copy of itself that is then translated to create a protein. At least in men, homosexuality may be a function of genetics, according to a study of more than 400 pairs of gay brothers. The research, published in Psychological Medicine, confirms the role of a stretch of the X chromosome in determining sexual preference in men, a finding first suggested more than 20 years ago. The Supreme Court is giving indications to voting on this matter down party lines. The one Justice all stake holders are paying special attention to is Justice Kennedy. Justice Kennedy. He said he was concerned about changing a conception of marriage that has persisted for thousands of years based on little more than a decade of experience with same-sex marriage in the United States.

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“I don’t even know how to count the decimals when we talk about millennia,” he said. “This definition has been with us for millennia. And it’s very difficult for the court to say, ‘Oh, well, we know better.’ ” He added that “the social science on this” — the value and perils of same-sex marriage — is “too new.” Later, though, he expressed qualms about excluding gay couples from the institution of marriage. “Same-sex couples say, of course: ‘We understand the nobility and the sacredness of the marriage. We know we can’t procreate but we want the other attributes of it in order to show that we, too, have a dignity that can be fulfilled,’ ” Justice Kennedy said, strongly suggesting that the reasoning resonated with him.

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One of the leading scientist on the question of can our genes decided if we are gay or not is Dean Hamer. Dean is an American geneticist, author, and filmmaker. He is known for his contributions to biotechnology and AIDS prevention, his research on the genetics of human behavior. Dean study in 1993 proposed , Xq28, a region of the X chromosome, might play a role in determining whether a man was gay.

The X chromosome (Xq28) in sexual orientation by DNA linkage analyses of two newly ascertained series of families that contained either two gay brothers or two lesbian sisters as well as heterosexual siblings. Linkage between the Xq28 markers and sexual orientation was detected for the gay male families but not for the lesbian families or for families that failed to meet defined inclusion criteria for the study of sex−linked sexual orientation. Our results corroborate the previously reported linkage between Xq28 and male homosexuality in selected kinships and suggest that this region contains a locus that influences individual variations in sexual orientation in men but not in women.

Duplications in the telomeric neighboring regions, which include GDP dissociation inhibitor 1 gene (GDI1) and ras-associated protein RAB39B gene (RAB39B), are independently associated with ID, and many segmental duplications located in this region could mediate these frequently observed interstitial duplications.

The only question now is there going to be a company in the United States to lead in building tools to find answers to question such as, is there a gene or genes associated with being a gay male. One organization we found to be performing creditable research in this area is the The German cDNA Consortium.

Stefan Wiemann (DKFZ), H. Blöcker (GBF Braunschweig); A. Bahr (Qiagen GmbH Hilden); K. Köhrer (BMFZ Düsseldorf); W. Ansorge (EMBL Heidelberg); H.W. Mewes (GSF München); B. Ottenwälder (Medigenomix GmbH München); D. Heubner (AGOWA GmbH Berlin)

The German cDNA Consortium (see below) was formed in 1996 as the world's second large-scale cDNA analysis project, and aimed at systematically generating (Wellenreuther 2004), sequencing and annotating full-length cDNAs of human genes. The resources produced in this project have been our contribution to the ORFeome Collaboration and have substantially helped to reach comprehensive coverage of the human genes in that resource.

While gene identification was initially through EST-sequencing of cDNA libraries (we generated ESTs from ~250,000 cDNAs, and completely sequenced 15,000 full-length cDNAs), we later shifted towards the directed modelling of gene structures and the cloning of respective ORFs. The project was part of the National Genome Research Network (NGFN). We have adapted and routinely apply the Gateway cloning system (Invitrogen) for the cloning of protein coding regions (ORFs) (Simpson 2000, Bechtel 2007). This system is based on recombination and allows for the base specific and directional cloning of DNA. With a high level of automation we amplify the ORFs in a 2-step PCR process, adding 5' and 3' flanking Gateway compatible sites. Universal `entry clones´ are generated via recombination, they are compatible with any Gateway expression vector. The entry clones are completely sequence verified as an important step in the quality control process. Inserts of verified entry clones are recombined into a range of expression vectors. These constructs are utilised in functional profiling to determine the sub-cellular localisation of encoded proteins (-> LIFEdb) and to identify cellular effects of protein overexpression in cell-based functional assays (Wiemann 2004, Starkuviene 2004, Arlt 2005, Laketa 2007, Sauermann 2007). Based on these screens, a number of new functions and disease associations could be associated with respective hits (Neubrand 2005, Fleischer 2006, Sauermann 2008). Furthermore, the clone resource has been exploited in a number of collaborative projects (e.g.,Will 2010, Bai 2011, Lisauskas 2012, Simpson 2012, Walde 2012)

The sequence resources and expertise of the German cDNA Consortium have been basis of the systematic functional annotation of the human transcriptome, which has been carried out by the international H-invitational consortium (Imanishi 2004, Yamasaki 2008). The complete annotation is publicly available in the H-invitational database (http://www.h-invitational.jp/).

The winner in this area of clinical research is Genomics Science. Just a taught when you are choosing a major.

Barron’s Medical Journal Breast Cancer Person Of The Year “Jeanne Rizzo “ & A Cure Report

Barron’s Medical Journal ---- B.Bobby Graham Reporting : ---- From Rice University Houston, TX USA < GlobeNewswire>< PRWire> < PRNewswire>

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Barron’s Medical Journal Breast Cancer Person Of The Year “Jeanne Rizzo “ & A Cure Report

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Barron’s 10th Annual person of the year award for their contribution to breast cancer and A breast cancer cure is Jeanne Rizzo. Jeanne works for The Breast Cancer Fund and a breast cancer survivor.

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Houston – ( AP ) -- Jeanne Rizzo’s vision guided the Breast Cancer Fund to adopt its bold mission to work to prevent breast cancer by eliminating our exposure to toxic chemicals and radiation linked to the disease. Under her direction the organization has become a national leader in translating the science linking breast cancer and environmental exposures into public education and advocacy campaigns that protect our health and reduce breast cancer risk.

Jeanne Rizzo President/CEO $ 173,580

Jeanne Rizzo’s vision guided the Breast Cancer Fund to adopt its bold mission of working to prevent breast cancer by eliminating exposure to toxic chemicals and radiation linked to the disease. Under her leadership the organization continues its commitment to strong science, smart public policy and consumer education. Ms. Rizzo co-chaired the National Institutes of Health’s Interagency Donald Pliner New Green Bottom Shoes Is The New Shoe Buzz Breast Cancer and Environmental Research Coordinating Committee, and is a recipient of the Environmental Protection Agency Region 9 Green Chemistry Environmental Leader Award. She is past chair of the California Breast Cancer Research Program Council and is a steering-committee member of the program’s Prevention Initiative. A nurse, then an award-winning music, theater and film producer, she produced the documentary Climb Against the Odds: Mt. McKinley, which chronicles the Breast Cancer Fund's 1998 expedition.

“when 1 in 8 women will be diagnosed with the disease, how much more awareness do we need? The Breast Cancer Fund is working to shift the conversation from awareness to prevention. We’re working to stop this disease before it starts, and we need the support of millions of people like you. You can start by pledging to go beyond the pink to prevention. “

In just a generation we’ve witnessed a 40-percent increase in breast cancer, and we know that environmental factors like toxic chemical exposures have played a major role. The Breast Cancer Fund is working to eliminate our exposure to toxic chemicals linked to the disease so that fewer of us, our daughters and increasingly our sons will ever have to hear the words, “You have breast cancer.”

Jeanne leads the organization’s strategic initiatives to remove the chemical bisphenol A, or BPA, from food packaging; to ensure cosmetics are non-toxic; and to overhaul the broken chemicals-management system that allows tens of thousands of toxic and untested chemicals to be used in consumer products. Recent legislative victories include the passage of a federal law banning toxic chemicals linked to breast cancer from toys, and California laws creating the first statewide biomonitoring program, advancing the safety of cosmetics and regulating chemicals in consumer products. Recent victories in the marketplace include a commitment from Campbell’s to remove BPA from its can linings and from Johnson & Johnson to globally reformulate its cosmetics products to remove harmful chemicals.

Breast Cancer Report Card Is A ( A ) ----- organizations like The Cancer Genome Atlas has made major advances in breast cancer research. Started in 2006 as a US $100-million pilot, The Cancer Genome Atlas (TCGA) is now the biggest component of the International Cancer Genome Consortium, a collaboration of scientists from 16 nations that has discovered nearly 10 million cancer-related mutations.

One of the best Research results is The Cancer Genome Atlas has identified four primary subtypes of breast cancer. Analyses of genomic data have confirmed that there are four primary subtypes of breast cancer, each with its own biology and survival outlooks. These TCGA findings are based on a large number of breast cancer specimens that capture a complete view of the genomic alterations. The four groups are called intrinsic subtypes of breast cancer: HER2-enriched (HER2E), Luminal A (LumA), Luminal B (LumB) and Basal-like. A fifth type, called Normal-like, was observed, but because of small numbers (only eight specimens) the researchers were unable to rigorously study it.

According to the World Health Organization, there are approximately 1.3 million new cases of breast cancer and 450,000 deaths worldwide annually. Breast cancer is the most common cancer among women. The majority of cases are sporadic, meaning there is not a family history of breast cancer, as opposed to genetic, where genes predispose a person to the disease.

Genomic Science has given the science community a opportunity to be optimistic about finding a cure. Our 1st Runner up for the person of the year is Dr. Staudt. Genomics is used in so many different ways for an example Dr. Staudt pioneered the use of gene expression profiling to discover molecularly and clinically distinct cancer subtypes and to predict response to therapy. He defined molecular subtypes of lymphoma that were previously unrecognized but are now viewed as distinct diseases that arise from different stages of B cell differentiation, utilize different oncogenic mechanisms and offer new therapeutic targets. To develop new treatments for lymphoid malignancies, Staudt’s laboratory uses various high-throughput approaches, including cancer gene resequencing, RNAi/CRISPR-based genetic screens, and combinatorial small molecule screens. The laboratory also conducts genomic investigations within therapeutic trials of targeted agents in lymphoma to define mechanisms of response and resistance.

Through The Cancer Genome Atlas (TCGA) (http://tcga.cancer.gov/), a joint effort of the National Cancer Institute and the National Human Genome Research Institute, we will greatly expand our understanding of the genetic basis of more than 20 cancers that affect adults and identify specific molecular changes that can be targeted for the development of new treatments or exploited to detect cancer earlier or prevent its occurrence.

The Top Rated Cancer Funds if you are looking for a tax deduction here is a list of Award winning organization to donate to says Barron’s Medical Journal

Breast Cancer Fund A-

Breast Cancer Research Foundation A+

Cancer Research Institute A Entertainment Industry Foundation A-

Leukemia and Lymphoma Society B+

LiveStrong Foundation A-

Memorial Sloan-Kettering Cancer Center A

Movember Foundation A

Multiple Myeloma Research Foundation A

National Breast Cancer Coalition Fund A

Ovarian Cancer Research Fund A Prevent Cancer Foundation B+

Prostate Cancer Foundation A

Can A Breast Cancer Cure Be Stopped -- By Supreme Court Justice Clarence Thomas:

Barron’s Medical Journal B.Bobby Graham reporting From The University Of Texas Austin -- Austin, TX USA Can A Breast Cancer Cure Be Stopped -- By Supreme Court Justice Clarence Thomas:

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Austin ----( AP ) Genomic Science has cleared the run way for a breast cancer cure. Barron’s Medical Journal is in Austin, Texas to report on the re- installation of the Cancer Prevention and Research Institute of Texas (CPRIT). Breast cancer scientist is using genomic science to find a cure more and more. This is great news for Texas scientist. Texas is one of the States in The United States to supply research grants to find cures for cancer. 89 % of cancer researchers interviewed say having more breast cancer patients going to the Doctor more often and being diagnosed early-- Donald Pliner New Green Bottom Shoes Is The New Shoe Buzz is a great help. With the Affordable Care Act (ACA or Obamacare) in place scientist can use genomic science to come up with a cure. Even the Microsoft Corporation has joined the race for a cure by using their Cloud Computing service to help scientist and Doctors to analyze breast cancer genome information.

Cancer Prevention and Research Institute of Texas (CPRIT) -- Texas voters overwhelmingly approved a constitutional amendment in 2007 establishing the Cancer Prevention and Research Institute of Texas (CPRIT) and authorizing the state to issue $3 billion in bonds to fund groundbreaking cancer research and prevention programs and services in Texas. CPRIT’s goal is to expedite innovation in cancer research and product development, and to enhance access to evidence-based prevention programs throughout the state. Under the guidance of its governing body, the Oversight Committee, CPRIT accepts applications and awards grants for a wide variety of cancer-related research and for the delivery of cancer prevention programs and services by public and private entities located in Texas. All CPRIT-funded research will be conducted in state by Texas-based scientists and reflect CPRIT’s mission to attract and expand the state’s research capabilities and create high quality new jobs in Texas.

CPRIT will maintain the highest integrity and dedication to the mission of finding a cure for cancer. CPRIT’s objective is to position Texas as a world-class leader in research and prevention through collaboration with a variety of entities, including public and private institutions of higher education, academic health institutions, universities, governmental organizations, nongovernmental organizations, public and private companies and others involved in the fight against cancer. CPRIT supports innovation in the selection of research projects emphasizing immediate or long-term medical breakthroughs; product development opportunities for research, and prevention services and health education for citizens with culturally appropriate information about ways in which their risks of developing and dying from cancer can be reduced.

Who is Clarence Thomas. Clarence Thomas was born on June 23, 1948, in Pin Point, Georgia. He served in the administrations of Reagan and George H.W. Bush. After the retirement of African-American Supreme Court Justice Thurgood Marshall led George H.W. Bush to nominate Thomas as his replacement and he was narrowly confirmed in 1991. Thomas is a conservative.

Barron’s Medical Journal has learned with Justice Thomas vote the Supreme court may overturn President Obama care. How can this happen? The matter before the court is King v. Burwell. If the plaintiffs in King v. Burwell are successful, an Obama Administration rule granting certain premium tax credits to those who obtain insurance through federal health care “exchanges” will be struck down. Absent action by the federal government or states, a ruling for the plaintiffs and against the Obama Administration would mean that individuals for whom insurance coverage became a greater out-of-pocket expense (exceeding 8 percent of their income in any given month) without the premium support tax credit would become exempt from the individual mandate. Furthermore, employers in states that refused to set up Obamacare exchanges would be exempt from the employer mandate because no federal outlays would be made to trigger the penalty. King is a consequential initial step on the road toward dismantling and replacing the ill-considered Obamacare statutory scheme. On March 4, the Supreme Court of the United States heard oral argument in King v. Burwell. This case is a challenge by individuals (petitioners) who do not wish to comply with the so-called minimum coverage provision of the Patient Protection and Affordable Care Act (ACA or Obamacare).

Millions of individuals in the 34 states served by the FFMs will lose their tax credits. Without the credits, they will no longer be able to afford health insurance. The cost of insurance to those remaining in the nongroup market will rise precipitously, causing even more Americans to lose coverage. As the number of uninsured increases, providers will bear an increased burden of uncompensated care. A decision for the plaintiffs, that is, will be disaster for the American health care system.

The challengers argue that this is a result Congress intended. They contend that the subsection of the Affordable Care Act dealing with the calculation of premium tax credits limits the credits to individuals enrolled in an “Exchange established by the State.”-- True & Real By Theresa Roemer The government argues that this is a term of art — that Congress intended this phrase to include the federally facilitated exchanges that the ACA requires the Department of Health and Human Services to create as a fallback where the states elect not to operate their own exchange. Dozens of other provisions of the ACA support the government’s position.

The federal district court in Virginia that originally heard the case ruled for the government, holding that the statute unambiguously supported the IRS rule. The Fourth Circuit Court of Appeals affirmed unanimously. The Fourth Circuit held that, although the government had the better argument, the statute was ambiguous; thus the IRS regulation should be upheld under the Chevron Rule, which requires courts to defer to administrative agency interpretations of statutory ambiguities. Judge Davis, concurring, concluded the statute clearly supported the IRS. In a highly unusual move, the Supreme Court took review of the case in the absence of a split between the circuits.

The argument was supposed to last an hour, but in fact went on for almost an hour and a half. It is a masterpiece—two highly competent counsel thoroughly in control of their arguments being grilled by Justices who had obviously read the briefs, thought about the issues, and prepared themselves to ask probing and difficult questions.

Although the question of standing came up again when Solicitor General Verrilli took the podium and one more time when Carvin returned for rebuttal, no one seemed eager to have the case decided on this basis at this point and everyone seemed ready to move on.

The meaning of exchange in the ACA. Justice Breyer did move on to press Carvin, repeating the key argument of the government that “exchange” is a defined term under the ACA. It is defined as a 1311 exchange, which in turn is defined as an exchange “established by a state.” Section 1321 requires HHS to set up “such exchange,” that is a “required” 1311 state exchange when a state elects not to do so. Having recited this argument, Breyer asked: “So what’s the problem?” Carvin responded, as he has all along, that the statute does not say an “exchange established under 1311,” but rather, an “Exchange established by the State under 1311.”

In response Justice Kagan posed a hypothetical. If she asked one of her clerks to write a memo, another to edit it, and a third to write it if the first was too busy, and the third in fact wrote it, should the second still edit it? Mr. Carvin, seeing where this was going (and aided by Justice Alito) protested the analogy because Congress in fact was not indifferent as to which clerk wrote the memo, that is, who set up the exchange. But, Justice Kagan responded, the only way we know whether Congress was indifferent is from the context of the four or five words on which the plaintiffs build their case, just as the context would determine the meaning of the instructions to the clerks.

Justice Breyer pressed on. Literally, under the statute the federal government establishes an exchange for the state, which the statute defines as an exchange established by the state. But even if you don’t read the statute literally, federal exchanges make no sense without tax credits.

Carvin pointed out that the ACA more literally defines territorial exchanges as equivalent to state exchanges, but the justices were not persuaded of the distinction. Interpreting the ACA to avoid unconstitutional coercion. And here they reached what may well prove to be the turning point of the argument. Justice Sotomayor pointed out that if the plaintiffs’ argument is right, states that elect not to operate their own exchanges face tremendous penalties. Not only do their residents lose the tax credits, but their nongroup insurance markets will collapse and they will be blocked from reducing Medicaid eligibility (and states that already have may lose Medicaid funding altogether). This is clearly, Sotomayor argued, unconstitutionally coercive under recent Supreme Court cases.

To predict the result of a case from oral argument, it seems the government came out of the argument on top. The government’s position is clearly supported by Justices Breyer, Kagan, Ginsburg, and Sotomayor. It seems to me that the government has a more than even shot at Justice Kennedy. It is clear that Justices Scalia and Alito are prepared to side with the challengers. The Chief Justice, however, did not clearly stake out a position one way or the other. Justice Thomas, as is his custom, was silent, although the government should probably draw no comfort from that. At this point it would change the legacy of Justice Thomas if he see this matter constitutional vitality and a breast cancer cure.